{"doi":"10.1128/mcb.12.9.4123-4131.1992","title":"A Cyclic AMP-Responsive Element-Binding Transcriptional Activator in <i>Drosophila melanogaster,</i> dCREB-A, Is a Member of the Leucine Zipper Family","abstract":null,"journal":"Molecular and Cellular Biology","year":1992,"id":685402,"datarank":0.5101796072493234,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.0,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1790656,"name":"Ronald E. Rose","orcid":null,"position":1,"is_corresponding":false},{"id":1210816,"name":"Richard H. Goodman","orcid":null,"position":2,"is_corresponding":false},{"id":1790655,"name":"Sarah M. Smolik","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Cyclic AMP-Responsive Element-Binding Transcriptional Activator in <i>Drosophila melanogaster,</i> dCREB-A, Is a Member of the Leucine Zipper Family","abstract":"In this report, we describe the isolation and initial characterization of a Drosophila protein, dCREB-A, that can bind the somatostatin cyclic AMP (cAMP)-responsive element and is capable of activating transcription in cell culture. Sequence analysis demonstrates that this protein is a member of the leucine zipper family of transcription factors. dCREB-A is unusual in that it contains six hydrophobic residue iterations in the zipper domain rather than the four or five commonly found in this group of proteins. The DNA-binding domain is more closely related to mammalian CREB than to the AP-1 factors in both sequence homology and specificity of cAMP-responsive element binding. In embryos, dCREB-A is expressed in the developing salivary gland. A more complex pattern of expression is detected in the adult; transcripts are found in the brain and optic lobe cell bodies, salivary gland, and midgut epithelial cells of the cardia. In females, dCREB-A is expressed in the ovarian columnar follicle cells, and in males, dCREB-A RNA is seen in the seminal vesicle, ejaculatory duct, and ejaculatory bulb. These results suggest that the dCREB-A transcription factor may be involved in fertility and neurological functions.","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1508208","pmcid":"PMC360311","openalex_id":"https://openalex.org/W4247619334","authors":[],"funders":[],"total_grants":0,"fwci":0.1399,"citation_percentile":0.47236001,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2023,"count":3},{"year":2024,"count":1}],"oa_status":"closed","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://journals.asm.org/doi/pdf/10.1128/mcb.12.9.4123-4131.1992","host_type":"publisher"},{"url":"https://www.tandfonline.com/doi/pdf/10.1128/mcb.12.9.4123-4131.1992","host_type":"publisher"},{"url":"https://doi.org/10.1128/mcb.12.9.4123-4131.1992","host_type":"journal"}],"fields_of_study":["Developmental Biology and Gene Regulation","Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","Animal Genetics and Reproduction","Amino Acid Sequence","Animals","Base Sequence","Blotting, Northern","Cyclic AMP Response Element-Binding Protein A","DNA","DNA-Binding Proteins","Drosophila Proteins","Drosophila melanogaster","Leucine Zippers","Molecular Sequence Data","Nucleic Acid Hybridization","Sequence Alignment","Trans-Activators","Transcription Factors","Transcription, Genetic"],"mesh_terms":["Animals","Drosophila melanogaster","DNA-Binding Proteins","Trans-Activators","Drosophila Proteins","Transcription Factors","DNA","Blotting, Northern","Nucleic Acid Hybridization","Sequence Alignment","Transcription, Genetic","Amino Acid Sequence","Base Sequence","Leucine Zippers","Molecular Sequence Data","Cyclic AMP Response Element-Binding Protein A"],"keywords":["Biology","Leucine zipper","ATF3","Transcription factor","Activating transcription factor 2","bZIP domain","CREB1","CREB","Basic helix-loop-helix leucine zipper transcription factors","Activating transcription factor","Molecular biology","Cell biology","Activator (genetics)","DNA-binding protein","Genetics","Promoter","Gene","Gene expression"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T16:34:57.195384Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}