{"doi":"10.1128/mcb.00574-16","title":"HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation","abstract":null,"journal":"Molecular and Cellular Biology","year":2017,"id":600547,"datarank":0.6010999777848708,"base_score":4.007333185232471,"endowment":4.007333185232471,"self_citation_contribution":0.6010999777848708,"citation_network_contribution":0.0,"self_endowment_contribution":0.6010999777848708,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":539195,"name":"Ran Zhuang","orcid":"0000-0002-3614-0422","position":1,"is_corresponding":false},{"id":518017,"name":"Lan Xiao","orcid":"0000-0003-1876-655X","position":2,"is_corresponding":false},{"id":293824,"name":"Hee Kyoung Chung","orcid":null,"position":3,"is_corresponding":false},{"id":637710,"name":"Jason Luo","orcid":null,"position":4,"is_corresponding":false},{"id":490258,"name":"Douglas J. Turner","orcid":"0000-0002-5244-0417","position":5,"is_corresponding":false},{"id":292775,"name":"Jaladanki N. Rao","orcid":"0000-0002-5669-8992","position":6,"is_corresponding":false},{"id":218108,"name":"Myriam Gorospe","orcid":"0000-0001-5439-3434","position":7,"is_corresponding":false},{"id":206335,"name":"Jian-Ying Wang","orcid":null,"position":8,"is_corresponding":false},{"id":440189,"name":"Lan Liu","orcid":"0000-0001-7642-6479","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation","abstract":"The mammalian intestinal mucosa exhibits a spectrum of responses after acute injury and repairs itself rapidly to restore the epithelial integrity. The RNA-binding protein HuR regulates the stability and translation of target mRNAs and is involved in many aspects of gut epithelium homeostasis, but its exact role in the regulation of mucosal repair after injury remains unknown. We show here that HuR is essential for early intestinal epithelial restitution by increasing the expression of cell division control protein 42 (Cdc42) at the posttranscriptional level. HuR bound to the Cdc42 mRNA via its 3′ untranslated region, and this association specifically enhanced Cdc42 translation without an effect on the Cdc42 mRNA level. Intestinal epithelium-specific HuR knockout not only decreased Cdc42 levels in mucosal tissues, but it also inhibited repair of damaged mucosa induced by mesenteric ischemia/reperfusion in the small intestine and by dextran sulfate sodium in the colon. Furthermore, Cdc42 silencing prevented HuR-mediated stimulation of cell migration over the wounded area by altering the subcellular distribution of F-actin. These results indicate that HuR promotes early intestinal mucosal repair after injury by increasing Cdc42 translation and demonstrate the importance of HuR deficiency in the pathogenesis of delayed mucosal healing in certain pathological conditions.","is_dataset_classified":null,"base_score":4.007333185232471,"endowment":4.007333185232471,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28031329","pmcid":null,"openalex_id":"https://openalex.org/W2561144307","authors":[],"funders":[{"funder_name":"NIH","grant_id":"DK57819 DK61972 DK68491","title":null},{"funder_name":"BLRD VA","grant_id":"I01 BX000332","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK057819","title":null},{"funder_name":"BLRD VA","grant_id":"I01 BX000713","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK068491","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK061972","title":null}],"total_grants":6,"fwci":2.7253,"citation_percentile":0.90597992,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":8},{"year":2019,"count":8},{"year":2020,"count":6},{"year":2021,"count":7},{"year":2022,"count":4},{"year":2023,"count":5},{"year":2024,"count":6},{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"bronze","license":"https://doi.org/10.1128/ASMCopyrightv1","oa_locations":[{"url":"https://mcb.asm.org/content/mcb/37/7/e00574-16.full.pdf","host_type":"journal"},{"url":"https://mcb.asm.org/content/mcb/37/7/e00574-16.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/MCB.00574-16","host_type":"publisher"},{"url":"https://www.tandfonline.com/doi/pdf/10.1128/MCB.00574-16","host_type":"publisher"},{"url":"https://doi.org/10.1128/mcb.00574-16","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28031329","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5359429","host_type":"repository"}],"fields_of_study":["RNA Research and Splicing","RNA modifications and cancer","Cancer-related molecular mechanisms research","3' Untranslated Regions","Animals","Cell Movement","Colitis","Dextran Sulfate","ELAV-Like Protein 1","Enterocytes","Gene Deletion","Gene Silencing","Humans","Intestinal Mucosa","Intestine, Small","Mice","Protein Binding","Protein Biosynthesis","RNA, Messenger","Rats","Wound Healing","cdc42 GTP-Binding Protein"],"mesh_terms":["ELAV-Like Protein 1","Animals","Cell Movement","Colitis","Humans","Intestinal Mucosa","Intestine, Small","Protein Binding","RNA, Messenger","Protein Biosynthesis","Wound Healing","Dextran Sulfate","Gene Deletion","3' Untranslated Regions","cdc42 GTP-Binding Protein","Gene Silencing","Enterocytes","Mice","Rats"],"keywords":["Intestinal epithelium","Biology","CDC42","Intestinal mucosa","Cell biology","Epithelium","Translation (biology)","Gene silencing","Messenger RNA","Molecular biology","Actin","Internal medicine","Biochemistry","Medicine","Genetics","Gene","cell migration","gut epithelial restitution","mRNA stability","mucosal homeostasis","small GTPases","translation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T13:26:47.423405Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}