{"doi":"10.1128/mcb.00547-19","title":"Unraveling the Hierarchy of <i>cis</i> and <i>trans</i> Factors That Determine the DNA Binding by Peroxisome Proliferator-Activated Receptor <i>γ</i>","abstract":"motif enrichment analysis and to define and classify high-affinity binding sites. We found that approximately half of the PPARγ cistrome represents direct DNA binding; both half sites can be extended upstream, and these are typically not of equal strength within a DR1. Strategically positioned LDTFs have greater impact on PPARγ binding than the quality of DR1, and the presence of the extension of DR1 provides a remarkable synergy with LDTFs. This approach of considering not only nucleotide frequencies but also their contribution to protein binding in a cellular context is applicable to other transcription factors.","journal":"Molecular and Cellular Biology","year":2020,"id":107049,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237496,"name":"Bence Dániel","orcid":"0000-0002-2410-8767","position":1,"is_corresponding":false},{"id":515223,"name":"Ixchelt Cuaranta‐Monroy","orcid":"0000-0001-7801-7695","position":2,"is_corresponding":false},{"id":483508,"name":"László Nagy","orcid":"0000-0001-6653-2155","position":3,"is_corresponding":false},{"id":483507,"name":"Gergely Nagy","orcid":"0000-0002-3273-731X","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T23:12:31.053776Z","pmid":"31932484","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}