{"doi":"10.1128/mbio.03708-21","title":"Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways","abstract":"sporozoites is a required step for infection of the organism. We found that alternate pathways of sporozoite liver infection differentially influence cerebral malaria (CM) development. CM is one of the primary causes of death following malaria infection. To date, CM research has focused on how CM phenotypes develop but no successful therapeutic treatment or prognostic biomarkers are available. Here we show for the first time that sporozoite liver invasion can trigger CM-inhibitory immune responses. Importantly, we identified a number of early-stage prognostic CM inhibitory biomarkers, many of which had never been associated with CM development. Serological markers identified using a mouse model are directly relevant to human CM.","journal":"mBio","year":2022,"id":284559,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9589,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":119472,"name":"Yu Xiang","orcid":"0000-0002-5593-5773","position":1,"is_corresponding":false},{"id":295584,"name":"Brian D. Gregory","orcid":"0000-0001-7532-0138","position":2,"is_corresponding":false},{"id":962322,"name":"Yong Seok Lee","orcid":"0000-0002-8687-589X","position":3,"is_corresponding":false},{"id":875134,"name":"Tomoko Ishino","orcid":"0000-0003-2466-711X","position":4,"is_corresponding":false},{"id":269837,"name":"Robert O. Opoka","orcid":"0000-0003-3240-2058","position":5,"is_corresponding":false},{"id":269834,"name":"Chandy C. John","orcid":"0000-0002-1634-1411","position":6,"is_corresponding":false},{"id":281698,"name":"Marcelo Jacobs‐Lorena","orcid":"0000-0003-0449-432X","position":7,"is_corresponding":false},{"id":725523,"name":"Sung‐Jae Cha","orcid":"0000-0003-0468-1723","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T00:29:36.828109Z","pmid":"35073748","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}