{"doi":"10.1128/mbio.03496-22","title":"Adjunctive Integrated Stress Response Inhibition Accelerates Tuberculosis Clearance in Mice","abstract":"Necrosis of lung lesions is a hallmark of tuberculosis (TB) that promotes bacterial growth, dissemination, and transmission. This process is driven by the persistent hyperactivation of the integrated stress response (ISR) pathway. Here, we show that adjunctive ISR inhibition during standard antibiotic therapy accelerates bacterial clearance and reduces immunopathology in a clinically relevant mouse model of TB, suggesting that host-directed therapies that de-escalate these pathological stress responses may shorten TB treatment durations. Our findings present an important conceptual advance toward overcoming the challenge of improving TB therapy and lowering the global burden of disease.","journal":"mBio","year":2023,"id":360291,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9461,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":561475,"name":"Pankaj Prasad","orcid":null,"position":1,"is_corresponding":false},{"id":351317,"name":"Shiqi Xiao","orcid":"0000-0001-5684-6580","position":2,"is_corresponding":false},{"id":352337,"name":"Shichun Lun","orcid":null,"position":3,"is_corresponding":false},{"id":241542,"name":"Camilo A. Ruiz-Bedoya","orcid":"0000-0002-0653-4244","position":4,"is_corresponding":false},{"id":491466,"name":"Mariah H. Klunk","orcid":null,"position":5,"is_corresponding":false},{"id":241541,"name":"Alvaro A. Ordoñez","orcid":"0000-0002-8571-0655","position":6,"is_corresponding":false},{"id":241543,"name":"Sanjay K. Jain","orcid":"0000-0001-9620-7070","position":7,"is_corresponding":false},{"id":745587,"name":"Geetha Srikrishna","orcid":null,"position":8,"is_corresponding":false},{"id":351323,"name":"Igor Kramnik","orcid":"0000-0001-6511-9246","position":9,"is_corresponding":false},{"id":241544,"name":"William R. Bishai","orcid":"0000-0002-8734-4118","position":10,"is_corresponding":false},{"id":644498,"name":"Stefanie Krug","orcid":"0000-0001-6390-3184","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T01:14:01.896928Z","pmid":"36853048","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}