{"doi":"10.1128/mbio.03400-21","title":"Variation in Host Resistance to Blastomyces dermatitidis: Potential Use of Genetic Reference Panels and Advances in Immunophenotyping of Diverse Mouse Strains","abstract":"Host genetic variation significantly impacts vulnerability to infectious diseases. While host variation in susceptibility to fungal infection with dimorphic fungi has long been recognized, genes that underpin this variation are poorly understood. We used a collection of seven mouse strains that represent nearly 90% of the genetic variation in mice to identify genetic variability among the strains in resistance to pulmonary infection with the dimorphic fungus Blastomyces dermatitidis. We analyzed differences between the strains in innate resistance by infecting naive mice and in acquired resistance by infecting vaccinated mice. We identified extreme variations in both innate and acquired resistance among the strains. In particular, we found sharp differences between C57BL/6 and DBA/2 strains in the ability to acquire vaccine-induced resistance. We also identified commercial reagents that allowed the phenotyping of immune cells from this strain collection of mice. Because there are additional mice harboring a genetic cross of the C57BL/6 and DBA/2 strains (BXD collection), such mice will permit future investigations to identify the genes that underlie differences in the ability to acquire resistance to infection.","journal":"mBio","year":2022,"id":292394,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7783,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":582503,"name":"Cleison Ledesma Taira","orcid":"0000-0001-9803-2366","position":1,"is_corresponding":false},{"id":361130,"name":"Hannah E. Dobson","orcid":"0000-0003-1246-880X","position":2,"is_corresponding":false},{"id":361131,"name":"Lucas dos Santos Dias","orcid":"0000-0003-2344-1354","position":3,"is_corresponding":false},{"id":663063,"name":"Uju Joy Okaa","orcid":"0000-0002-8246-3521","position":4,"is_corresponding":false},{"id":286954,"name":"Darin L. Wiesner","orcid":null,"position":5,"is_corresponding":false},{"id":362749,"name":"Marcel Wüthrich","orcid":null,"position":6,"is_corresponding":false},{"id":284650,"name":"Bruce S. Klein","orcid":"0000-0003-3212-1539","position":7,"is_corresponding":false},{"id":361132,"name":"Elaine M. Kohn","orcid":"0000-0001-6282-760X","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T00:30:46.209549Z","pmid":"35089087","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}