{"doi":"10.1128/mbio.03384-22","title":"The ER Protein Translocation Channel Subunit Sbh1 Controls Virulence of Cryptococcus neoformans","abstract":"Cryptococcus neoformans is a yeast that causes almost 200,000 deaths worldwide each year, mainly of immunocompromised individuals. The surface structures of this pathogen, a protective cell wall surrounded by a polysaccharide capsule, are made and maintained by proteins that are synthesized inside the cell and travel outwards through the secretory pathway. A protein called Sbh1 is part of the machinery that determines which polypeptides enter this export pathway. We found that when Sbh1 is absent, both C. neoformans and the model yeast S. cerevisiae show cell-wall defects. Lack of Sbh1 also changes the pattern of secretion of both transmembrane and soluble proteins, in a manner that depends on characteristics of their sequences. Notably, multiple proteins that are normally upregulated in conditions similar to those encountered during infection, including several needed for cryptococcal virulence, are no longer increased. Sbh1 thereby regulates the ability of this important pathogen to cause disease.","journal":"mBio","year":2023,"id":363510,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9466,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1003782,"name":"Thomas Hurtaux","orcid":"0000-0002-1633-5329","position":1,"is_corresponding":false},{"id":521088,"name":"Jennifer Geddes‐McAlister","orcid":"0000-0002-4257-2096","position":2,"is_corresponding":false},{"id":1003783,"name":"Duy Nguyen","orcid":"0000-0002-4852-4538","position":3,"is_corresponding":false},{"id":756301,"name":"Volkhard Helms","orcid":"0000-0002-2180-9154","position":4,"is_corresponding":false},{"id":273286,"name":"Tamara L. Doering","orcid":"0000-0002-5179-7393","position":5,"is_corresponding":false},{"id":1003784,"name":"Karin Römisch","orcid":"0000-0003-0415-6558","position":6,"is_corresponding":false},{"id":871299,"name":"Felipe H. Santiago‐Tirado","orcid":"0000-0002-6453-4904","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-19T01:14:28.054440Z","pmid":"36749043","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}