{"doi":"10.1128/mbio.03343-19","title":"Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates <i>PRKCA</i>","abstract":"Globally, diarrhea remains one of the major causes of pediatric morbidity and mortality. The initial symptoms of diarrhea can often lead to long-term consequences for the health of young children, such as malnutrition and neurocognitive developmental deficits. Despite many children having similar exposures to infectious causes of diarrhea, not all develop symptomatic disease, indicating a possible role for human genetic variation. Here, we conducted a genetic study of susceptibility to symptomatic disease associated with Cryptosporidium infection (a leading cause of diarrhea) in three independent cohorts of infants from Dhaka, Bangladesh. We identified a genetic variant within protein kinase C alpha ( PRKCA ) associated with higher risk of cryptosporidiosis in the first year of life. These results indicate a role for human genetics in susceptibility to cryptosporidiosis and warrant further research to elucidate the mechanism.","journal":"mBio","year":2020,"id":75891,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":395851,"name":"Poonum Korpe","orcid":"0000-0002-2008-0912","position":1,"is_corresponding":false},{"id":59337,"name":"Chelsea Marie","orcid":"0000-0001-8193-2771","position":2,"is_corresponding":false},{"id":83854,"name":"Alexander J. Mentzer","orcid":"0000-0002-4502-2209","position":3,"is_corresponding":false},{"id":395852,"name":"Tommy Carstensen","orcid":"0000-0002-3672-9931","position":4,"is_corresponding":false},{"id":24831,"name":"Josyf C. Mychaleckyj","orcid":"0000-0003-2595-0005","position":5,"is_corresponding":false},{"id":246860,"name":"Beth D. Kirkpatrick","orcid":"0000-0002-7016-7338","position":6,"is_corresponding":false},{"id":11274,"name":"Stephen S. Rich","orcid":"0000-0003-3872-7793","position":7,"is_corresponding":false},{"id":395853,"name":"Patrick Concannon","orcid":"0000-0002-5801-1859","position":8,"is_corresponding":false},{"id":395854,"name":"Abu Syed Golam Faruque","orcid":"0000-0001-8343-4653","position":9,"is_corresponding":false},{"id":289251,"name":"Rashidul Haque","orcid":"0000-0001-5100-136X","position":10,"is_corresponding":false},{"id":59357,"name":"William A. Petri Jr.","orcid":"0000-0002-7268-1218","position":11,"is_corresponding":false},{"id":115227,"name":"Priya Duggal","orcid":"0000-0001-5809-2081","position":12,"is_corresponding":false},{"id":247496,"name":"Genevieve L. Wojcik","orcid":"0000-0001-7206-8088","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-18T21:46:55.856612Z","pmid":"32019797","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}