{"doi":"10.1128/mbio.03287-20","title":"The ChiS-Family DNA-Binding Domain Contains a Cryptic Helix-Turn-Helix Variant","abstract":", the transcription factor ChiS directly regulates gene expression through a cryptic DNA-binding domain. This domain lacked homology to any known DNA-binding protein. In the current study, we determined the structure of the ChiS DNA-binding domain (DBD) and found that the ChiS-family DBD is a cryptic variant of the ubiquitous helix-turn-helix (HTH) domain. We further demonstrate that this domain is conserved in diverse proteins that may represent a novel group of transcriptional regulators.","journal":"mBio","year":2021,"id":198303,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":530033,"name":"G. Minasov","orcid":"0000-0001-5460-3462","position":1,"is_corresponding":false},{"id":587940,"name":"Ram Podicheti","orcid":"0000-0003-3449-5155","position":2,"is_corresponding":false},{"id":4131,"name":"Douglas B. Rusch","orcid":"0000-0002-1066-2687","position":3,"is_corresponding":false},{"id":337589,"name":"Triana N. Dalia","orcid":"0000-0001-7614-1377","position":4,"is_corresponding":false},{"id":36778,"name":"Karla J. F. Satchell","orcid":"0000-0003-3274-7611","position":5,"is_corresponding":false},{"id":336887,"name":"Matthew B. Neiditch","orcid":"0000-0002-7039-4469","position":6,"is_corresponding":false},{"id":278678,"name":"Ankur B. Dalia","orcid":"0000-0003-2203-1230","position":7,"is_corresponding":false},{"id":454761,"name":"Catherine A. Klancher","orcid":"0000-0002-0085-9224","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:50:27.616568Z","pmid":"33727356","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}