{"doi":"10.1128/mbio.03280-22","title":"Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation","abstract":"The microbiota is a potent reservoir of immunostimulatory and immunosuppressive motifs that fundamentally shape host immunity. Despite broad associations between microbial composition and host immunity, the mechanisms underlying host microbiota-induced immunoregulation remain poorly defined. Here, we demonstrate a novel mechanism by which motifs overabundant during dysbiotic conditions influence host immunity through the upregulation of endogenous RT to produce motifs that agonize antiviral receptors.","journal":"mBio","year":2023,"id":360062,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1111490,"name":"Bhavya Singh","orcid":"0000-0001-6641-6429","position":1,"is_corresponding":false},{"id":1111491,"name":"Stephanie Michael","orcid":"0000-0001-6438-2587","position":2,"is_corresponding":false},{"id":1111492,"name":"Morgan M. O’Mara","orcid":"0000-0002-2671-4234","position":3,"is_corresponding":false},{"id":295823,"name":"Jez L. Marston","orcid":"0000-0001-9784-7926","position":4,"is_corresponding":false},{"id":1111493,"name":"Tongyi Fei","orcid":"0000-0002-6926-9556","position":5,"is_corresponding":false},{"id":355307,"name":"Matthew L. Bendall","orcid":"0000-0001-9816-5425","position":6,"is_corresponding":false},{"id":295826,"name":"Douglas F. Nixon","orcid":"0000-0002-2801-1786","position":7,"is_corresponding":false},{"id":259015,"name":"Nicholas Dopkins","orcid":"0000-0001-6128-2089","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T01:14:01.896928Z","pmid":"36645307","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}