{"doi":"10.1128/mbio.03059-20","title":"Merkel Cell Polyomavirus Encodes Circular RNAs (circRNAs) Enabling a Dynamic circRNA/microRNA/mRNA Regulatory Network","abstract":"Covalently closed circular RNAs were recently described in the human DNA tumor viruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), and human papillomavirus (HPV). Here, we show that MCV, another DNA tumor virus, generates circRNAs from its early regulatory region in concert with T antigen linear transcripts. MCV circMCV-T interacts with another MCV noncoding RNA, miR-M1, to functionally modulate early region transcript expression important for viral replication and long-term episomal persistence. This work describes a dynamic regulatory network integrating circRNA/miRNA/mRNA biomolecules and underscores the intricate functional modulation between several classes of polyomavirus-encoded RNAs in the control of viral replication.","journal":"mBio","year":2020,"id":67211,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9563,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":356068,"name":"Hongzhao Zhou","orcid":"0000-0003-2109-4184","position":1,"is_corresponding":false},{"id":356069,"name":"Jinghui Li","orcid":"0000-0003-2193-1288","position":2,"is_corresponding":false},{"id":356070,"name":"Simon Cao","orcid":"0000-0002-5348-5705","position":3,"is_corresponding":false},{"id":356071,"name":"Tuna Toptan","orcid":"0000-0002-5399-9263","position":4,"is_corresponding":false},{"id":13510,"name":"Adam Grundhoff","orcid":"0000-0003-0940-7045","position":5,"is_corresponding":false},{"id":28472,"name":"Nicole Fischer","orcid":"0000-0001-7401-9271","position":6,"is_corresponding":false},{"id":343734,"name":"Patrick S. Moore","orcid":"0000-0002-8132-858X","position":7,"is_corresponding":false},{"id":51648,"name":"Yuan Chang","orcid":"0000-0003-1125-4041","position":8,"is_corresponding":false},{"id":356067,"name":"Bizunesh Abere","orcid":"0000-0002-1857-4374","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-18T21:15:12.020735Z","pmid":"33323517","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}