{"doi":"10.1128/mbio.03039-22","title":"Structural Foundations of Potassium Selectivity in Channelrhodopsins","abstract":"Recently discovered microbial light-gated ion channels (channelrhodopsins) with a higher permeability for K + than for Na + (potassium-selective channelrhodopsins [kalium channelrhodopsins, or KCRs]) demonstrate an alternative K + selectivity mechanism, unrelated to well-characterized “selectivity filters” of voltage- and ligand-gated K + channels. KCRs can be used for optogenetic inhibition of neuronal firing and potentially for the development of gene therapies to treat neurological and cardiovascular disorders.","journal":"mBio","year":2022,"id":253023,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":299115,"name":"Oleg A. Sineshchekov","orcid":"0000-0002-6358-7764","position":1,"is_corresponding":false},{"id":299118,"name":"Leonid S. Brown","orcid":"0000-0002-5614-8317","position":2,"is_corresponding":false},{"id":325933,"name":"Ana‐Nicoleta Bondar","orcid":"0000-0003-2636-9773","position":3,"is_corresponding":false},{"id":266443,"name":"John L. Spudich","orcid":"0000-0003-4167-8590","position":4,"is_corresponding":false},{"id":299114,"name":"Elena G. Govorunova","orcid":"0000-0003-0522-9683","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T00:24:55.325369Z","pmid":"36413022","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}