{"doi":"10.1128/mbio.02981-22","title":"Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi","abstract":"The spirochete Borreliella burgdorferi is a causative agent of Lyme disease, the most common tickborne disease in the United States. The spirochete is transmitted to humans during the course of a tick taking a bloodmeal. After B. burgdorferi is deposited into the skin of a human host, it replicates locally and spreads systemically, often resulting in clinical manifestations involving the central nervous system, joints, and/or heart. Antibodies directed against B. burgdorferi's outer surface protein C (OspC) are known to block tick-to-host transmission, as well as dissemination of the spirochete within a mammalian host. In this report, we reveal the first atomic structure of one such antibody in complex with OspC. Our results have implications for the design of a Lyme disease vaccine capable of interfering with multiple stages in B. burgdorferi infection.","journal":"mBio","year":2023,"id":344138,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":511324,"name":"Simon Davis","orcid":"0000-0001-7840-2411","position":1,"is_corresponding":false},{"id":1012255,"name":"H. M. Emranul Haque","orcid":null,"position":2,"is_corresponding":false},{"id":445965,"name":"David D. Weis","orcid":"0000-0003-3032-1211","position":3,"is_corresponding":false},{"id":430649,"name":"David J. Vance","orcid":"0000-0002-9913-7722","position":4,"is_corresponding":false},{"id":423478,"name":"Carol Lyn Piazza","orcid":null,"position":5,"is_corresponding":false},{"id":249880,"name":"Monir Ejemel","orcid":"0000-0001-9155-5914","position":6,"is_corresponding":false},{"id":249894,"name":"Lisa A. Cavacini","orcid":"0000-0003-1417-8339","position":7,"is_corresponding":false},{"id":249896,"name":"Yang Wang","orcid":"0000-0002-5554-8247","position":8,"is_corresponding":false},{"id":399217,"name":"Moustapha Mbow","orcid":"0000-0002-5745-2628","position":9,"is_corresponding":false},{"id":452084,"name":"Robert D. Gilmore","orcid":null,"position":10,"is_corresponding":false},{"id":45735,"name":"Nicholas J. Mantis","orcid":"0000-0002-5083-8640","position":11,"is_corresponding":false},{"id":511323,"name":"M. Rudolph","orcid":"0000-0002-5893-9817","position":0,"is_corresponding":true}],"reference_count":102,"raw_metadata":null,"created_at":"2026-07-19T01:11:30.951510Z","pmid":"36976016","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}