{"doi":"10.1128/mbio.02916-22","title":"Why Molnupiravir Fails in Hospitalized Patients","abstract":"In this study, we showed that early intervention with molnupiravir resulted in a greater antiviral effect, and we explained the mechanism behind this phenomenon. Our results predicted and explained the failure of molnupiravir in hospitalized patients and highlighted the utility of preclinical pharmacodynamic studies to design optimal antiviral regimens for the treatment of viral diseases. This contrasts with the procedure that was implemented early in the pandemic in which clinical studies were conducted in the absence of preclinical experimentation. These findings are significant and demonstrated the importance of experimental approaches in antiviral development for treatments against COVID-19 as well as other viral diseases.","journal":"mBio","year":2022,"id":271259,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":361328,"name":"Yinzhi Lang","orcid":"0000-0002-6857-4516","position":1,"is_corresponding":false},{"id":300099,"name":"Jieqiang Zhou","orcid":null,"position":2,"is_corresponding":false},{"id":936648,"name":"Evelyn J. Franco","orcid":null,"position":3,"is_corresponding":false},{"id":936649,"name":"Kaley C. Hanrahan","orcid":null,"position":4,"is_corresponding":false},{"id":298093,"name":"Jürgen B. Bulitta","orcid":"0000-0001-7352-3097","position":5,"is_corresponding":false},{"id":361338,"name":"George L. Drusano","orcid":"0000-0001-9162-7332","position":6,"is_corresponding":false},{"id":34150,"name":"Ashley N. Brown","orcid":"0000-0001-9993-5241","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T00:27:35.206187Z","pmid":"36374076","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}