{"doi":"10.1128/mbio.02911-19","title":"Staphylococcus epidermidis MSCRAMM SesJ Is Encoded in Composite Islands","abstract":"S. epidermidis is an opportunistic bacterium that has established itself as a successful nosocomial pathogen. The modern era of novel therapeutics and medical devices has extended the longevity of human life, but at the same time, we also witness the evolution of pathogens to adapt to newly available niches in the host. Increasing antibiotic resistance among pathogens provides an example of such pathogen adaptation. With limited opportunities to modify the core genome, most of the adaptation occurs by acquiring new genes, such as virulence factors and antibiotic resistance determinants present in MGEs. In this study, we describe that the sesJ gene, encoding a recently discovered cell wall-anchored protein in S. epidermidis , is present in both ACME and the SCC element. The presence of virulence factors in MGEs can influence the virulence potential of a specific strain. Therefore, it is critical to study the virulence factors found in MGEs in emerging pathogenic bacteria or strains to understand the mechanisms used by these bacteria to cause infections.","journal":"mBio","year":2020,"id":80947,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":419471,"name":"Xiqi Li","orcid":"0000-0003-0875-8337","position":1,"is_corresponding":false},{"id":419472,"name":"Andrew Hillhouse","orcid":"0000-0003-4874-7077","position":2,"is_corresponding":false},{"id":420971,"name":"Kranti Konganti","orcid":null,"position":3,"is_corresponding":false},{"id":419473,"name":"Sara V. Little","orcid":"0000-0003-3908-593X","position":4,"is_corresponding":false},{"id":419474,"name":"Sara D. Lawhon","orcid":"0000-0001-9154-8909","position":5,"is_corresponding":false},{"id":262707,"name":"David W. Threadgill","orcid":"0000-0003-3538-1635","position":6,"is_corresponding":false},{"id":90441,"name":"Samuel A. Shelburne","orcid":"0000-0001-9721-263X","position":7,"is_corresponding":false},{"id":364583,"name":"Magnus Höök","orcid":"0000-0003-2703-0309","position":8,"is_corresponding":false},{"id":370089,"name":"Srishtee Arora","orcid":null,"position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-18T21:52:34.401799Z","pmid":"32071265","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}