{"doi":"10.1128/mbio.02807-19","title":"EspM Is a Conserved Transcription Factor That Regulates Gene Expression in Response to the ESX-1 System","abstract":"Mycobacterial pathogens use the ESX-1 system to transport protein substrates that mediate essential interactions with the host during infection. We previously demonstrated that in addition to transporting proteins, the ESX-1 secretion system regulates gene expression. Here, we identify a conserved transcription factor that regulates gene expression in response to the ESX-1 system. We demonstrate that this transcription factor is functionally conserved in M. marinum , a pathogen of ectothermic animals; M. tuberculosis , the human-pathogenic species that causes tuberculosis; and M. smegmatis , a nonpathogenic mycobacterial species. These findings provide the first mechanistic insight into how the ESX-1 system elicits a transcriptional response, a function of this protein transport system that was previously unknown.","journal":"mBio","year":2020,"id":93148,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":465436,"name":"Micah J. Ferrell","orcid":"0000-0003-3364-5676","position":1,"is_corresponding":false},{"id":466576,"name":"Alexandra E. Chirakos","orcid":null,"position":2,"is_corresponding":false},{"id":425940,"name":"Kathleen R. Nicholson","orcid":"0000-0002-6152-0259","position":3,"is_corresponding":false},{"id":312550,"name":"Robert B. Abramovitch","orcid":"0000-0002-4119-4169","position":4,"is_corresponding":false},{"id":416106,"name":"Matthew M. Champion","orcid":"0000-0001-5927-5277","position":5,"is_corresponding":false},{"id":465437,"name":"Patricia A. Champion","orcid":"0000-0002-6733-596X","position":6,"is_corresponding":false},{"id":465435,"name":"Kevin Sanchez","orcid":"0000-0003-1627-4172","position":0,"is_corresponding":true}],"reference_count":101,"raw_metadata":null,"created_at":"2026-07-18T22:30:54.208860Z","pmid":"32019792","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}