{"doi":"10.1128/mbio.02787-23","title":"A novel conjugative transposon carrying an autonomously amplified plasmid","abstract":"The exchange of antibiotic production and resistance genes between microorganisms can lead to the emergence of new pathogens. In this study, short-read mapping of metagenomic samples taken over time from the illeal pouch of a patient with ulcerative colitis to a Bacteroides fragilis metagenome-assembled genome revealed two distinct genomic arrangements of a novel conjugative transposon, CTn214, that encodes tetracycline resistance. The autonomous amplification of a plasmid-like circular form from CTn214 that includes tetQ potentially provides consistent ribosome protection against tetracycline. This mode of antibiotic resistance offers a novel mechanism for understanding the emergence of pathobionts like B. fragilis and their persistence for extended periods of time in patients with inflammatory bowel disease.","journal":"mBio","year":2024,"id":460719,"datarank":0.22826053704646476,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.020316382878481153,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.020316382878481153,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9524,"is_data_producer":true,"deposit_databanks":{"BioProject":["PRJNA1027366"],"GENBANK":["OR675140"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":115525,"name":"William S. Reznikoff","orcid":null,"position":1,"is_corresponding":false},{"id":263526,"name":"Dionysios A. Antonopoulos","orcid":"0000-0002-2238-5031","position":2,"is_corresponding":false},{"id":570057,"name":"Jason Koval","orcid":"0000-0003-4270-0534","position":3,"is_corresponding":false},{"id":109507,"name":"Eugene B. Chang","orcid":"0000-0001-5972-8248","position":4,"is_corresponding":false},{"id":1289337,"name":"Bailey Fallon","orcid":null,"position":5,"is_corresponding":false},{"id":1177943,"name":"Blair G. Paul","orcid":"0000-0002-5738-5568","position":6,"is_corresponding":false},{"id":237852,"name":"Hilary G. Morrison","orcid":"0000-0003-0281-326X","position":7,"is_corresponding":false},{"id":569873,"name":"Mitchell L. Sogin","orcid":"0000-0002-7196-6991","position":8,"is_corresponding":false},{"id":1288844,"name":"Joseph H. Vineis","orcid":"0000-0002-4101-1449","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:04:07.925246Z","pmid":"38259081","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}