{"doi":"10.1128/mbio.02772-20","title":"Structure of the Receptor Binding Domain of EnvP(b)1, an Endogenous Retroviral Envelope Protein Expressed in Human Tissues","abstract":"Organisms can access genetic and functional novelty by capturing viral elements within their genomes, where they can evolve to drive new cellular or organismal processes. We demonstrate that a retroviral envelope gene, EnvP(b)1, has been maintained and its fusion activity preserved for 40 to 71 million years. It is expressed as a protein in multiple healthy human tissues. We determined the structure of its inferred receptor binding domain and compared it with the same domain in modern viruses. We found a common conserved architecture that underlies the varied receptor binding activity of divergent Env genes. The modularity and versatility of this domain may underpin the evolutionary success of this clade of fusogens.","journal":"mBio","year":2020,"id":83102,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9458,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":429220,"name":"Joseph L. Timpona","orcid":null,"position":1,"is_corresponding":false},{"id":258816,"name":"Simon Jenni","orcid":"0000-0001-5722-5890","position":2,"is_corresponding":false},{"id":226293,"name":"Louis-Marie Bloyet","orcid":"0000-0002-5648-3190","position":3,"is_corresponding":false},{"id":428105,"name":"Vesna Brusic","orcid":"0000-0002-8447-3520","position":4,"is_corresponding":false},{"id":428106,"name":"Welkin E. Johnson","orcid":"0000-0001-5991-5414","position":5,"is_corresponding":false},{"id":103752,"name":"Sean P. J. Whelan","orcid":"0000-0003-1564-8590","position":6,"is_corresponding":false},{"id":428107,"name":"Lindsey R. Robinson‐McCarthy","orcid":"0000-0002-8066-2770","position":7,"is_corresponding":false},{"id":428104,"name":"Kevin R. McCarthy","orcid":"0000-0003-1016-6015","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T21:54:09.383533Z","pmid":"33203760","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}