{"doi":"10.1128/mbio.02510-21","title":"Neutralization of SARS-CoV-2 Variants of Concern Harboring Q677H","abstract":"SARS-CoV-2, the causative agent of COVID-19, is rapidly evolving to be more transmissible and to evade acquired immunity. To date, most investigations of SARS-CoV-2 variants have focused on RBD mutations. However, the impact of non-RBD mutations and their synergy with studied RBD mutations are poorly understood. Here, we examine the role of the non-RBD Q677H mutation arising in many SARS-CoV-2 lineages, including VOCs. We demonstrate that the Q677H mutation enhances viral infectivity and confers neutralizing antibody resistance, particularly in the background of other SARS-CoV-2 VOCs.","journal":"mBio","year":2021,"id":158205,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":47,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":278003,"name":"John P. Evans","orcid":"0000-0001-8644-5825","position":1,"is_corresponding":false},{"id":666619,"name":"Julia N. Faraone","orcid":"0000-0002-3421-4707","position":2,"is_corresponding":false},{"id":278005,"name":"Panke Qu","orcid":"0000-0002-0222-365X","position":3,"is_corresponding":false},{"id":278006,"name":"Yi-Min Zheng","orcid":"0000-0002-0394-9735","position":4,"is_corresponding":false},{"id":227281,"name":"Linda J. Saif","orcid":"0000-0002-3224-9009","position":5,"is_corresponding":false},{"id":244459,"name":"Eugene M. Oltz","orcid":"0000-0002-2513-7156","position":6,"is_corresponding":false},{"id":278008,"name":"Gerard Lozanski","orcid":"0000-0002-5095-0456","position":7,"is_corresponding":false},{"id":629721,"name":"Richard J. Gumina","orcid":"0000-0001-8298-1129","position":8,"is_corresponding":false},{"id":278002,"name":"Cong Zeng","orcid":"0000-0003-4423-3634","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-18T23:44:26.210708Z","pmid":"34607452","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}