{"doi":"10.1128/mbio.02473-21","title":"A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants","abstract":"The U.S. FDA has issued emergency use authorizations (EUAs) for multiple investigational monoclonal antibody (MAb) therapies for the treatment of mild to moderate COVID-19. These MAb therapeutics are solely targeting the receptor-binding domain of the SARS-CoV-2 spike protein. However, the N-terminal domain of the spike protein also carries crucial neutralizing epitopes. Here, we show that key mutations in the N-terminal domain can reduce the neutralizing capacity of convalescent-phase COVID-19 sera. We report that a combination of two neutralizing antibodies targeting the receptor-binding and N-terminal domains may be beneficial to combat the emergence of virus variants.","journal":"mBio","year":2021,"id":154942,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":61,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":109530,"name":"M. Eugenia Dieterle","orcid":"0000-0002-5257-7253","position":1,"is_corresponding":false},{"id":109524,"name":"Anna Z. Wec","orcid":"0000-0002-2134-2152","position":2,"is_corresponding":false},{"id":109545,"name":"Cecilia M. O’Brien","orcid":"0000-0001-7160-0220","position":3,"is_corresponding":false},{"id":109528,"name":"Mrunal Sakharkar","orcid":"0000-0002-2717-5201","position":4,"is_corresponding":false},{"id":109543,"name":"Catalina Florez","orcid":"0000-0002-0407-861X","position":5,"is_corresponding":false},{"id":552492,"name":"Karen Tong","orcid":"0000-0002-2976-2864","position":6,"is_corresponding":false},{"id":17254,"name":"C. Garrett Rappazzo","orcid":"0000-0002-8415-444X","position":7,"is_corresponding":false},{"id":240439,"name":"Gorka Lasso","orcid":"0000-0001-5355-323X","position":8,"is_corresponding":false},{"id":187436,"name":"Olivia Vergnolle","orcid":null,"position":9,"is_corresponding":false},{"id":109541,"name":"Ariel S. Wirchnianski","orcid":"0000-0002-3953-8954","position":10,"is_corresponding":false},{"id":109540,"name":"Robert H. Bortz","orcid":"0000-0003-1751-2152","position":11,"is_corresponding":false},{"id":109542,"name":"Ethan Laudermilch","orcid":"0000-0001-7488-1718","position":12,"is_corresponding":false},{"id":109544,"name":"J. Maximilian Fels","orcid":"0000-0003-1455-9318","position":13,"is_corresponding":false},{"id":240441,"name":"Amanda Mengotto","orcid":"0000-0001-6383-422X","position":14,"is_corresponding":false},{"id":240442,"name":"Ryan J. Malonis","orcid":"0000-0002-5759-3180","position":15,"is_corresponding":false},{"id":240443,"name":"George I. Georgiev","orcid":"0000-0002-1323-7600","position":16,"is_corresponding":false},{"id":240444,"name":"Jose A. Quiroz","orcid":"0000-0001-8525-930X","position":17,"is_corresponding":false},{"id":87305,"name":"Daniel Wrapp","orcid":"0000-0002-0538-9647","position":18,"is_corresponding":false},{"id":87306,"name":"Nianshuang Wang","orcid":"0000-0002-7569-011X","position":19,"is_corresponding":false},{"id":657589,"name":"Kathryn E. Dye","orcid":null,"position":20,"is_corresponding":false},{"id":240445,"name":"Jason Barnhill","orcid":"0000-0001-9051-4256","position":21,"is_corresponding":false},{"id":109549,"name":"John M. Dye","orcid":"0000-0002-0883-5016","position":22,"is_corresponding":false},{"id":87312,"name":"Jason S. McLellan","orcid":"0000-0003-3991-542X","position":23,"is_corresponding":false},{"id":75972,"name":"Johanna P. Daily","orcid":"0000-0003-2506-1072","position":24,"is_corresponding":false},{"id":240446,"name":"Jonathan R. Lai","orcid":"0000-0002-4863-0015","position":25,"is_corresponding":false},{"id":109525,"name":"Andrew S. Herbert","orcid":"0000-0003-4697-7928","position":26,"is_corresponding":false},{"id":109550,"name":"Laura M. Walker","orcid":"0000-0001-7704-3197","position":27,"is_corresponding":false},{"id":109548,"name":"Kartik Chandran","orcid":"0000-0003-0232-7077","position":28,"is_corresponding":false},{"id":109529,"name":"Rohit K. Jangra","orcid":"0000-0002-3119-0869","position":29,"is_corresponding":false},{"id":109527,"name":"Denise Haslwanter","orcid":"0000-0003-2727-0468","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T23:43:59.154159Z","pmid":"34607456","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}