{"doi":"10.1128/mbio.02188-21","title":"The Intersection of the Staphylococcus aureus Rex and SrrAB Regulons: an Example of Metabolic Evolution That Maximizes Resistance to Immune Radicals","abstract":"<jats:p>\n            Pathogens must evolve virulence potential to improve transmission to new hosts as well as evolve metabolically to thrive within their current host.\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus</jats:named-content>\n            has achieved both of these, and here, we show that one such metabolic adaptation was the expansion of the Rex regulon. First, it affords\n            <jats:named-content content-type=\"genus-species\">S. aureus</jats:named-content>\n            with efficient respiration-independent growth critical to surviving the inflammatory environment replete with respiration-inhibiting immune radicals.\n          </jats:p>","journal":"mBio","year":2021,"id":640593,"datarank":0.4636563680037475,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.0,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":982383,"name":"Xingru Chen","orcid":"0000-0001-9131-3798","position":1,"is_corresponding":false},{"id":1664933,"name":"Elyse Paluscio","orcid":null,"position":2,"is_corresponding":false},{"id":1122578,"name":"Amelia C. 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First, it affords\n            <jats:named-content content-type=\"genus-species\">S. aureus</jats:named-content>\n            with efficient respiration-independent growth critical to surviving the inflammatory environment replete with respiration-inhibiting immune radicals.\n          </jats:p>","is_dataset_classified":null,"base_score":3.091042453358316,"endowment":3.091042453358316,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34781744","pmcid":"PMC8593685","openalex_id":"https://openalex.org/W3211614791","authors":[],"funders":[{"funder_name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","grant_id":"R01AI093613","title":null},{"funder_name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","grant_id":"5T32AI060525","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"T32 AI060525","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01AI093613-08","title":"The Metabolic Evolution of Staphylococcus aureus"},{"funder_name":"National Institutes of Health","grant_id":"2T32AI060525-16A1","title":"Immunology of Infections Disease Renewal 2023"}],"total_grants":5,"fwci":0.8673,"citation_percentile":0.77095335,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2023,"count":6},{"year":2024,"count":5},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1128/mbio.02188-21","host_type":"journal"},{"url":"https://doi.org/10.1128/mbio.02188-21","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/mBio.02188-21","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34781744","host_type":"repository"},{"url":"https://doaj.org/article/4857bdd29c764cdf94a2a390fb1ec488","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8593685","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8593685","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8593685?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1128/mBio.02188-21","host_type":""},{"url":"https://dx.doi.org/10.1128/mbio.02188-21","host_type":""}],"fields_of_study":["Antimicrobial Resistance in Staphylococcus","Bacterial Genetics and Biotechnology","Bacterial biofilms and quorum sensing","0301 basic medicine","0303 health sciences","03 medical and health sciences","Anaerobiosis","Bacterial Proteins","Evolution, Molecular","Gene Expression Regulation, Bacterial","Humans","Nitric Oxide","Regulon","Repressor Proteins","Staphylococcal Infections","Staphylococcus aureus"],"mesh_terms":["Anaerobiosis","Bacterial Proteins","Humans","Nitric Oxide","Repressor Proteins","Staphylococcal Infections","Staphylococcus aureus","Gene Expression Regulation, Bacterial","Regulon","Evolution, Molecular"],"keywords":["Regulon","Staphylococcus aureus","Virulence","Gene","Bacteria","Human pathogen","Fermentation","Metabolism","Nitric oxide","Redox Signaling","Metabolic Evolution","Coagulase-negative Staphylococci","Immune Radicals","Gene Expression Regulation, Bacterial","Staphylococcal Infections","Microbiology","QR1-502","Evolution, Molecular","Repressor Proteins","Bacterial Proteins","Humans","Anaerobiosis","Research Article"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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