{"doi":"10.1128/mbio.01979-21","title":"Differential Expression of CREM/ICER Isoforms Is Associated with the Spontaneous Control of HIV Infection","abstract":"A small group of HIV-infected individuals, termed elite controllers (ECs), display control of HIV replication in the absence of antiretroviral therapy (ART). However, the mechanism of ECs' resistance to HIV replication is not clear. In our work, we found an increased expression of specific, small isoforms of ICER in ECs. Further experiments proved that ICER is a robust host factor to regulate viral replication. Furthermore, we found that ICER regulates HIV LTR promoter activity in a Tat-dependent manner. These findings suggest that ICER is related to spontaneous control of HIV infection in ECs. This study may help elucidate a novel target for treatment of HIV.","journal":"mBio","year":2022,"id":289085,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":110145,"name":"Min Li","orcid":"0000-0002-1220-062X","position":1,"is_corresponding":false},{"id":800898,"name":"Tai-Wei Li","orcid":"0000-0002-7364-0805","position":2,"is_corresponding":false},{"id":227430,"name":"Zongyang Lv","orcid":"0000-0002-8862-113X","position":3,"is_corresponding":false},{"id":737725,"name":"Zhiwei Ye","orcid":"0000-0001-7537-2739","position":4,"is_corresponding":false},{"id":827845,"name":"William J. Cisneros","orcid":"0000-0003-2472-6167","position":5,"is_corresponding":false},{"id":426397,"name":"Jie Zhang","orcid":"0000-0002-0466-2955","position":6,"is_corresponding":false},{"id":697930,"name":"Lingmin Yuan","orcid":"0000-0002-2289-3175","position":7,"is_corresponding":false},{"id":36741,"name":"Judd F. Hultquist","orcid":"0000-0001-6424-4280","position":8,"is_corresponding":false},{"id":427784,"name":"Stephen A. Migueles","orcid":"0000-0002-6062-8022","position":9,"is_corresponding":false},{"id":970272,"name":"Lei Huang","orcid":"0000-0003-0380-8104","position":10,"is_corresponding":false},{"id":277769,"name":"Jian Zhu","orcid":"0000-0001-9856-8320","position":11,"is_corresponding":false},{"id":789626,"name":"Wei Jiang","orcid":"0000-0003-2769-2812","position":12,"is_corresponding":false},{"id":365575,"name":"Zhenwu Luo","orcid":null,"position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T00:30:18.766838Z","pmid":"35041523","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}