{"doi":"10.1128/mbio.01743-21","title":"Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity","abstract":"Given the suboptimal outcome of VRC01 antibody-mediated prevention of HIV-1 infection in its first field trial, means to improve diverse antiviral activities in vivo have renewed importance. This work revisits a loss-of-function experiment that investigated the mechanism of action of b12, a similar antibody, and finds that the reason why complement-mediated antiviral activities were not observed to contribute to protection may be the inherent lack of activity of wild-type b12, raising the prospect that this mechanism may contribute in the context of other HIV-specific antibodies.","journal":"mBio","year":2021,"id":198669,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.948,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":554340,"name":"Chengzi I. Kaku","orcid":"0000-0002-9854-8351","position":1,"is_corresponding":false},{"id":350098,"name":"Jérémy Dufloo","orcid":"0000-0002-4963-1378","position":2,"is_corresponding":false},{"id":773990,"name":"Timothée Bruel","orcid":"0000-0002-3952-4261","position":3,"is_corresponding":false},{"id":292388,"name":"Olivier Schwartz","orcid":"0000-0002-0729-1475","position":4,"is_corresponding":false},{"id":426534,"name":"David A. Spencer","orcid":"0000-0002-5789-6202","position":5,"is_corresponding":false},{"id":347938,"name":"Ann J. Hessell","orcid":"0000-0001-7471-9366","position":6,"is_corresponding":false},{"id":291270,"name":"Margaret E. Ackerman","orcid":"0000-0002-4253-3476","position":7,"is_corresponding":false},{"id":773989,"name":"Benjamin S. Goldberg","orcid":"0000-0002-7468-3487","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-18T23:50:31.857233Z","pmid":"34634936","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}