{"doi":"10.1128/mbio.01405-21","title":"Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells","abstract":"Highly conserved epitopes within the coreceptor binding site (CoRBS) and constant region 1 and 2 (C1-C2 or cluster A) are only available for antibody recognition after the HIV-1 Env trimer binds host cell CD4; therefore, they are not accessible on virions and infected cells, where the expression of CD4 is downregulated. Here, we have developed new antibody fusion molecules in which domains 1 and 2 of soluble human CD4 are linked with monoclonal antibodies of either the CoRBS or cluster A specificity.","journal":"mBio","year":2021,"id":182306,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":443635,"name":"Dung N. Nguyen","orcid":"0009-0006-7168-3234","position":1,"is_corresponding":false},{"id":335146,"name":"William D. Tolbert","orcid":"0000-0001-7549-9596","position":2,"is_corresponding":false},{"id":241564,"name":"Romain Gasser","orcid":"0000-0002-8565-1106","position":3,"is_corresponding":false},{"id":241572,"name":"Shilei Ding","orcid":"0000-0003-1895-5131","position":4,"is_corresponding":false},{"id":443633,"name":"Dani Vézina","orcid":"0000-0002-0780-8593","position":5,"is_corresponding":false},{"id":443634,"name":"Shang Yu Gong","orcid":"0000-0001-8211-6207","position":6,"is_corresponding":false},{"id":241563,"name":"Jérémie Prévost","orcid":"0000-0002-5260-5154","position":7,"is_corresponding":false},{"id":241575,"name":"Gabrielle Gendron‐Lepage","orcid":"0000-0002-2671-3872","position":8,"is_corresponding":false},{"id":243836,"name":"Halima Medjahed","orcid":null,"position":9,"is_corresponding":false},{"id":546420,"name":"Suneetha Gottumukkala","orcid":null,"position":10,"is_corresponding":false},{"id":241588,"name":"Andrés Finzi","orcid":"0000-0002-4992-5288","position":11,"is_corresponding":false},{"id":335148,"name":"Marzena Pazgier","orcid":"0000-0003-0594-5057","position":12,"is_corresponding":false},{"id":241566,"name":"Jonathan Richard","orcid":"0000-0002-9015-9589","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:48:09.223560Z","pmid":"34579568","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}