{"doi":"10.1128/mbio.01278-23","title":"Citrate cross-feeding by <i>Pseudomonas aeruginosa</i> supports <i>lasR</i> mutant fitness","abstract":"Cross-feeding of metabolites can change community composition, structure, and function. Here, we unravel a cross-feeding mechanism between frequently co-observed isolate genotypes in chronic Pseudomonas aeruginosa lung infections. We illustrate an example of how clonally derived diversity in a microbial communication system enables intra- and inter-species cross-feeding. Citrate, a metabolite released by many cells including P. aeruginosa and Staphylococcus aureus , was differentially consumed between genotypes. Since these two pathogens frequently co-occur in the most severe cystic fibrosis lung infections, the cross-feeding-induced virulence factor expression and fitness described here between diverse genotypes exemplify how co-occurrence can facilitate the development of worse disease outcomes.","journal":"mBio","year":2024,"id":433539,"datarank":0.5029126560910002,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.10705405664871127,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.10705405664871127,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":10,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.948,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":298218,"name":"Carson Finger","orcid":"0000-0002-0335-4547","position":1,"is_corresponding":false},{"id":1239263,"name":"Amy Conaway","orcid":"0000-0002-4174-2268","position":2,"is_corresponding":false},{"id":304677,"name":"Nico J. Botelho","orcid":"0000-0002-5307-659X","position":3,"is_corresponding":false},{"id":1171980,"name":"Stacie E. Stuut","orcid":"0000-0001-9723-7677","position":4,"is_corresponding":false},{"id":456,"name":"Deborah A. Hogan","orcid":"0000-0002-6366-2971","position":5,"is_corresponding":false},{"id":56029,"name":"Dallas L. Mould","orcid":"0000-0001-6939-1351","position":0,"is_corresponding":true}],"reference_count":95,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:59:49.434790Z","pmid":"38259061","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}