{"doi":"10.1128/mbio.01163-21","title":"CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle","abstract":"Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers. In this report, we demonstrate that phosphorylation of HPV16 E2 by CK2 promotes formation of a complex with the cellular protein TopBP1 in vitro and in vivo .","journal":"mBio","year":2021,"id":165909,"datarank":0.5416376868966337,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"self_citation_contribution":0.5416376868966337,"citation_network_contribution":0.0,"self_endowment_contribution":0.5416376868966337,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":325354,"name":"Claire D. James","orcid":"0000-0002-6816-1607","position":1,"is_corresponding":false},{"id":691400,"name":"Dipon Das","orcid":null,"position":2,"is_corresponding":false},{"id":691401,"name":"Raymonde Otoa","orcid":null,"position":3,"is_corresponding":false},{"id":690458,"name":"M.W. Day","orcid":"0000-0001-7218-867X","position":4,"is_corresponding":false},{"id":217275,"name":"John W. Burgner","orcid":null,"position":5,"is_corresponding":false},{"id":690459,"name":"Christian T. Fontan","orcid":"0000-0002-3981-7478","position":6,"is_corresponding":false},{"id":350299,"name":"Xu Wang","orcid":"0000-0003-4781-5250","position":7,"is_corresponding":false},{"id":691402,"name":"Sarah H. Glass","orcid":null,"position":8,"is_corresponding":false},{"id":241860,"name":"Andreas Wieland","orcid":"0000-0001-9648-7922","position":9,"is_corresponding":false},{"id":690460,"name":"Mary Donaldson","orcid":"0000-0002-1936-3499","position":10,"is_corresponding":false},{"id":690461,"name":"Molly L. Bristol","orcid":"0000-0002-4259-8528","position":11,"is_corresponding":false},{"id":585822,"name":"Renfeng Li","orcid":"0000-0002-9226-4470","position":12,"is_corresponding":false},{"id":691403,"name":"Anthony W. Oliver","orcid":null,"position":13,"is_corresponding":false},{"id":690462,"name":"Laurence H. Pearl","orcid":"0000-0002-6910-1809","position":14,"is_corresponding":false},{"id":576883,"name":"Brian O. Smith","orcid":"0000-0003-3363-4168","position":15,"is_corresponding":false},{"id":325358,"name":"Iain M. Morgan","orcid":"0000-0002-4949-3032","position":16,"is_corresponding":false},{"id":690457,"name":"Apurva T. Prabhakar","orcid":"0000-0003-2266-7247","position":0,"is_corresponding":true}],"reference_count":111,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:45:45.220559Z","pmid":"34544280","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}