{"doi":"10.1128/mbio.01013-21","title":"Interactions between Viral Regulatory Proteins Ensure an MOI-Independent Probability of Lysogeny during Infection by Bacteriophage P1","abstract":"Phage P1 has been shown potentially to play an important role in disseminating antibiotic resistance among bacteria during lysogenization, as evidenced by the prevalence of P1 phage-like elements in animal and human pathogens. In contrast to phage λ, a cell fate decision-making paradigm, P1 lysogenization was shown to be independent of MOI. In this work, we built a simple genetic model to elucidate this MOI independency based on the gene-regulatory circuitry of P1. We also proposed that the effective communication between coinfecting phages contributes to the lysis-lysogeny decision-making of P1 and highlighted the significance of spatial organization in the process of cell fate determination in a single-cell environment. Finally, our work provides new insights into different strategies acquired by viruses to interact with their bacterial hosts in different scenarios for their optimal survival.","journal":"mBio","year":2021,"id":178752,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":725268,"name":"Kiara Pankratz","orcid":null,"position":1,"is_corresponding":false},{"id":725269,"name":"Hau Duong","orcid":null,"position":2,"is_corresponding":false},{"id":724751,"name":"Matthew Theodore","orcid":"0000-0003-0625-7141","position":3,"is_corresponding":false},{"id":486405,"name":"Jingwen Guan","orcid":"0000-0003-1759-2172","position":4,"is_corresponding":false},{"id":724752,"name":"Anxiao Jiang","orcid":"0000-0002-0120-7930","position":5,"is_corresponding":false},{"id":724753,"name":"Yiruo Lin","orcid":"0000-0002-9293-6126","position":6,"is_corresponding":false},{"id":331340,"name":"Lanying Zeng","orcid":"0000-0002-8074-5824","position":7,"is_corresponding":false},{"id":440237,"name":"Kailun Zhang","orcid":"0000-0002-6994-9033","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-18T23:47:40.592580Z","pmid":"34517752","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}