{"doi":"10.1128/mbio.00502-21","title":"Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts","abstract":"Periodontitis is a highly prevalent disease caused by accumulation of a bacterial biofilm. Periodontal pathogens use a number of virulence strategies that are under intensive study to find optimal therapeutic approaches against bone loss. In our work, we present a novel mechanism utilized by the key periodontal pathogen Porphyromonas gingivalis, based on the selective degradation of the negative regulator of inflammation, MCPIP-1. We found that the diminished levels of MCPIP-1 in gingival keratinocytes-cells at the forefront of the fight against bacteria-cause sensitization to endotoxins produced by other oral species. This results in an enhanced inflammatory response, which promotes the growth of inflammophilic pathobionts and damage of tooth-supporting tissues. Our observation is relevant to understanding the molecular basis of periodontitis and the development of new methods for treatment.","journal":"mBio","year":2021,"id":189226,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":751323,"name":"Ewelina Dobosz","orcid":"0000-0002-0151-9723","position":1,"is_corresponding":false},{"id":496286,"name":"Barbara Potempa","orcid":"0000-0002-1226-6952","position":2,"is_corresponding":false},{"id":751324,"name":"Izabela Ciastoń","orcid":"0000-0001-7545-0135","position":3,"is_corresponding":false},{"id":231324,"name":"Mateusz Wilamowski","orcid":"0000-0001-8760-0700","position":4,"is_corresponding":false},{"id":751325,"name":"Zuzanna Oruba","orcid":"0000-0001-6370-7538","position":5,"is_corresponding":false},{"id":339037,"name":"Richard J. Lamont","orcid":"0000-0002-3147-5039","position":6,"is_corresponding":false},{"id":171760,"name":"Jolanta Jura","orcid":"0000-0002-0816-3475","position":7,"is_corresponding":false},{"id":271717,"name":"Jan Potempa","orcid":"0000-0002-3600-7461","position":8,"is_corresponding":false},{"id":496284,"name":"Joanna Kozieł","orcid":"0000-0003-3436-6425","position":9,"is_corresponding":false},{"id":751322,"name":"Anna Gąsiorek","orcid":"0000-0003-3172-4901","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T23:49:14.547082Z","pmid":"34182783","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}