{"doi":"10.1128/mbio.00386-22","title":"Generation of Mature DENVs via Genetic Modification and Directed Evolution","abstract":"and are the target for vaccine development. Here, we used multiple strategies, including protein engineering and natural and directed evolution to generate DENV1, -2, -3, and -4 variants that are highly mature without compromising replication efficiency compared to the parental strains. Given the clinical importance of mature DENVs in immunity, this work provides a roadmap for engineering highly mature DENV that could apply to future vaccine development. Our directed-evolution data also shed light on the divergent evolutionary relationship of DENVs between its host and vector.","journal":"mBio","year":2022,"id":244190,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9504,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":277822,"name":"Rita M. Meganck","orcid":"0000-0003-2799-3754","position":1,"is_corresponding":false},{"id":816366,"name":"Stephanie Dong","orcid":"0000-0002-0318-5261","position":2,"is_corresponding":false},{"id":109139,"name":"Lily E. Adams","orcid":"0000-0001-7780-9973","position":3,"is_corresponding":false},{"id":355497,"name":"Laura White","orcid":"0000-0002-1859-4981","position":4,"is_corresponding":false},{"id":376982,"name":"Michael L. Mallory","orcid":"0000-0003-0768-572X","position":5,"is_corresponding":false},{"id":103774,"name":"Ramesh Jadi","orcid":"0000-0002-5710-4893","position":6,"is_corresponding":false},{"id":103776,"name":"Aravinda M. de Silva","orcid":null,"position":7,"is_corresponding":false},{"id":5952,"name":"Ralph S. Baric","orcid":"0000-0001-6827-8701","position":8,"is_corresponding":false},{"id":104944,"name":"Longping V. Tse","orcid":"0000-0001-7582-8396","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T00:23:25.718788Z","pmid":"35481749","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}