{"doi":"10.1128/mbio.00367-22","title":"C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major <i>Acinetobacter baumannii</i> Carbapenemase OXA-23 by Impeding Deacylation","abstract":"Carbapenem antibiotics are the drugs of choice for treatment of deadly infections caused by Gram-negative bacteria. However, their efficacy is severely compromised by the wide spread of carbapenem-hydrolyzing class D β-lactamases (CHDLs). The importance of this research is the discovery that substitution of the canonical hydroxyethyl group of carbapenems by a hydroxymethyl significantly enhances stability against inactivation by the major CHDL of Acinetobacter baumannii, OXA-23. These results provide a novel strategy for designing next-generation, carbapenemase-stable carbapenems to fight multidrug-resistant infections caused by Gram-negative pathogens.","journal":"mBio","year":2022,"id":259702,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":389143,"name":"Márta Tóth","orcid":"0000-0002-0442-1553","position":1,"is_corresponding":false},{"id":709548,"name":"Maha A. Alqurafi","orcid":null,"position":2,"is_corresponding":false},{"id":709549,"name":"Weirui Chai","orcid":null,"position":3,"is_corresponding":false},{"id":438282,"name":"Thu Nguyen","orcid":"0000-0002-4778-8830","position":4,"is_corresponding":false},{"id":709550,"name":"Pojun Quan","orcid":null,"position":5,"is_corresponding":false},{"id":364756,"name":"Mijoon Lee","orcid":"0000-0001-7432-0427","position":6,"is_corresponding":false},{"id":709005,"name":"John D. Buynak","orcid":"0000-0003-1007-791X","position":7,"is_corresponding":false},{"id":389144,"name":"Clyde A. Smith","orcid":"0000-0002-1885-1511","position":8,"is_corresponding":false},{"id":389145,"name":"Sergei B. Vakulenko","orcid":"0000-0002-5327-8124","position":9,"is_corresponding":false},{"id":389794,"name":"Nichole K. Stewart","orcid":null,"position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-19T00:25:58.993402Z","pmid":"35420470","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}