{"doi":"10.1128/mbio.00339-23","title":"Targeting Sterylglucosidase A to Treat Aspergillus fumigatus Infections","abstract":"Invasive fungal infections are a leading cause of death in immunocompromised patients. Aspergillus fumigatus is a fungus ubiquitously found in the environment that, upon inhalation, causes both acute and chronic illnesses in at-risk individuals. A. fumigatus is recognized as one of the critical fungal pathogens for which a substantive treatment breakthrough is urgently needed. Here, we studied a fungus-specific enzyme, sterylglucosidase A (SglA), as a therapeutic target. We identified selective inhibitors of SglA that induce accumulation of sterylglucosides and delay filamentation in A. fumigatus and increase survival in a murine model of pulmonary aspergillosis. We determined the structure of SglA, predicted the binding poses of these inhibitors through docking analysis, and identified a more efficacious derivative with a limited SAR study. These results open several exciting avenues for the research and development of a new class of antifungal agents targeting sterylglucosidases.","journal":"mBio","year":2023,"id":374367,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9562,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1071745,"name":"Kalani Jayanetti","orcid":"0000-0002-3477-945X","position":1,"is_corresponding":false},{"id":1136324,"name":"Dominick Rendina","orcid":null,"position":2,"is_corresponding":false},{"id":720129,"name":"Timothy Clement","orcid":null,"position":3,"is_corresponding":false},{"id":1136325,"name":"Verônica S. Brauer","orcid":null,"position":4,"is_corresponding":false},{"id":564029,"name":"Caroline Mota Fernandes","orcid":null,"position":5,"is_corresponding":false},{"id":500541,"name":"Iwao Ojima","orcid":"0000-0002-3628-1161","position":6,"is_corresponding":false},{"id":348775,"name":"Michael V. Airola","orcid":"0000-0003-4981-1253","position":7,"is_corresponding":false},{"id":329325,"name":"Maurizio Del Poeta","orcid":"0000-0001-8418-3120","position":8,"is_corresponding":false},{"id":329323,"name":"Nívea Pereira de Sá","orcid":"0000-0003-0901-6909","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:16:11.341687Z","pmid":"36877042","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}