{"doi":"10.1128/mbio.00240-22","title":"A Comprehensive Phenotypic Screening Strategy to Identify Modulators of Cargo Translocation by the Bacterial Type IVB Secretion System","abstract":"Multi-drug-resistant pathogens are an emerging threat to human health. Because conventional antibiotics target not only the pathogen but also eradicate the beneficial microbiota, they often cause additional clinical complications. Thus, there is an urgent need for the development of \"smarter\" therapeutics that selectively target pathogens without affecting beneficial commensals. The bacterial type IV secretion system (T4SS) is essential for the virulence of a variety of pathogens but dispensable for bacterial viability in general and can, thus, be considered a pathogen's Achilles heel. By identifying small molecules that interfere with cargo delivery by the T4SS from two important human pathogens, Legionella pneumophila and Coxiella burnetii, our study represents the first step in our pursuit toward precision medicine by developing pathogen-selective therapeutics capable of treating the infections without causing harm to commensal bacteria.","journal":"mBio","year":2022,"id":281186,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9556,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":457725,"name":"Dorjbal Dorjsuren","orcid":null,"position":1,"is_corresponding":false},{"id":355588,"name":"Stephanie S. Lehman","orcid":"0000-0002-4568-3082","position":2,"is_corresponding":false},{"id":690545,"name":"C. L. Larson","orcid":"0000-0002-0924-0604","position":3,"is_corresponding":false},{"id":712410,"name":"Steven A. Titus","orcid":null,"position":4,"is_corresponding":false},{"id":332246,"name":"Hongmao Sun","orcid":"0000-0003-4042-6498","position":5,"is_corresponding":false},{"id":12541,"name":"Alexey Zakharov","orcid":"0000-0003-2466-1711","position":6,"is_corresponding":false},{"id":268294,"name":"Ganesha Rai","orcid":"0000-0001-9763-9641","position":7,"is_corresponding":false},{"id":303822,"name":"Robert A. Heinzen","orcid":"0000-0001-6870-4619","position":8,"is_corresponding":false},{"id":228423,"name":"Anton Simeonov","orcid":"0000-0002-4523-9977","position":9,"is_corresponding":false},{"id":341969,"name":"Matthias P. Machner","orcid":"0000-0002-6971-7451","position":10,"is_corresponding":false},{"id":956038,"name":"Eric Cheng","orcid":"0000-0002-4769-4420","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:29:07.472902Z","pmid":"35258332","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}