{"doi":"10.1128/mbio.00136-20","title":"Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response","abstract":"Although the interferon (IFN) signaling pathway is a key host mechanism to restrict infection of a diverse range of viral pathogens, its unrestrained activity either at baseline or in the context of an immune response can result in host cell damage and injury. Here, we used a genome-wide CRISPR-Cas9 screen and identified the DNA binding protein Barrier-to-autointegration factor 1 (Banf1) as a modulator of basal cell-intrinsic immunity. A loss of Banf1 expression resulted in higher level of cytosolic double-stranded DNA at baseline, which triggered IFN-stimulated gene expression via a cGAS-STING-IRF3 axis that did not require type I IFN or STAT1 signaling. Our experiments define a regulatory network in which Banf1 limits basal inflammation by preventing self DNA accumulation in the cytosol.","journal":"mBio","year":2020,"id":66796,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9572,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":328043,"name":"Wei Qian","orcid":"0000-0002-2970-5069","position":1,"is_corresponding":false},{"id":353781,"name":"Monika Bambousková","orcid":"0000-0002-8022-4092","position":2,"is_corresponding":false},{"id":244451,"name":"Patrick L. Collins","orcid":"0000-0003-4550-4272","position":3,"is_corresponding":false},{"id":248085,"name":"Sofia I. Porter","orcid":null,"position":4,"is_corresponding":false},{"id":353782,"name":"Andrea K. Byrum","orcid":"0000-0002-5597-8933","position":5,"is_corresponding":false},{"id":249780,"name":"Rong Zhang","orcid":"0000-0003-2941-4808","position":6,"is_corresponding":false},{"id":52958,"name":"Maxim N. Artyomov","orcid":"0000-0002-1133-4212","position":7,"is_corresponding":false},{"id":244459,"name":"Eugene M. Oltz","orcid":"0000-0002-2513-7156","position":8,"is_corresponding":false},{"id":353783,"name":"Nima Mosammaparast","orcid":"0000-0001-5453-5914","position":9,"is_corresponding":false},{"id":328037,"name":"Jonathan J. Miner","orcid":"0000-0001-9551-2962","position":10,"is_corresponding":false},{"id":106529,"name":"Michael Diamond","orcid":"0000-0002-8791-3165","position":11,"is_corresponding":false},{"id":230321,"name":"Hongming Ma","orcid":"0000-0001-5105-1332","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-18T21:14:50.590588Z","pmid":"32156810","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}