{"doi":"10.1128/mbio.00009-23","title":"A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains","abstract":"With a small genome of ~9.2 kb that encodes 14 major proteins, HIV must hijack host cellular machinery to successfully establish infection. These host proteins necessary for HIV replication are called \"dependency factors.\" Whole-genome, and then targeted screens were done to try to comprehensively identify all dependency factors acting throughout the HIV replication cycle. Many host processes were identified and validated as critical for HIV replication across multiple HIV strains.","journal":"mBio","year":2023,"id":357600,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":998736,"name":"Trine M. Ready","orcid":null,"position":1,"is_corresponding":false},{"id":349171,"name":"Abby Felton","orcid":null,"position":2,"is_corresponding":false},{"id":998150,"name":"Sydney R. Fine","orcid":"0000-0003-2700-9489","position":3,"is_corresponding":false},{"id":347028,"name":"Molly OhAinle","orcid":"0000-0001-5138-5367","position":4,"is_corresponding":false},{"id":103702,"name":"Michael Emerman","orcid":"0000-0002-4181-6335","position":5,"is_corresponding":false},{"id":998149,"name":"Vanessa R. Montoya","orcid":"0000-0002-6754-7874","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T01:13:39.186262Z","pmid":"36744886","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}