{"doi":"10.1128/jvi.80.3.1271-1279.2006","title":"Functional Analyses of RNA Structures Shared between the Internal Ribosome Entry Sites of Hepatitis C Virus and the Picornavirus Porcine Teschovirus 1 Talfan","abstract":"<jats:title>ABSTRACT</jats:title><jats:p>The internal ribosome entry site (IRES) of porcine teschovirus 1 (PTV-1), a member of the<jats:italic>Picornaviridae</jats:italic>family, is quite distinct from other well-characterized picornavirus IRES elements, but it displays functional similarities to the IRES from hepatitis C virus (HCV), a member of the<jats:italic>Flaviviridae</jats:italic>family. In particular, a dominant negative mutant form of eIF4A does not inhibit the activity of the PTV-1 IRES. Furthermore, there is a high level (ca. 50%) of identity between the PTV-1 and HCV IRES sequences. A secondary-structure model of the whole PTV-1 IRES has been derived which includes a pseudoknot. Validation of specific features within the model has been achieved by mutagenesis and functional assays. The differences and similarities between the PTV-1 and HCV IRES elements should assist in defining the critical features of this type of IRES.</jats:p>","journal":"Journal of Virology","year":2006,"id":22804,"datarank":2.640834510763789,"base_score":4.04305126783455,"endowment":4.04305126783455,"self_citation_contribution":0.6064576901751826,"citation_network_contribution":2.0343768205886064,"self_endowment_contribution":0.6064576901751826,"citer_contribution":2.0343768205886064,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":45,"citers_with_citation_signal":43,"citers_with_endowment":43,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":142155,"name":"Yoshihiro Kaku","orcid":null,"position":1,"is_corresponding":false},{"id":142156,"name":"Barbara Jones","orcid":null,"position":2,"is_corresponding":false},{"id":142157,"name":"Arabinda Nayak","orcid":null,"position":3,"is_corresponding":false},{"id":137827,"name":"Graham J. Belsham","orcid":null,"position":4,"is_corresponding":false},{"id":142154,"name":"Louisa S. Chard","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.04305126783455,"endowment":4.04305126783455,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16415004","pmcid":"PMC1346926","openalex_id":"https://openalex.org/W2122821069","authors":[],"funders":[],"total_grants":0,"fwci":4.7338,"citation_percentile":0.95333105,"influential_citations":4,"citation_trend":[{"year":2012,"count":2},{"year":2014,"count":4},{"year":2015,"count":3},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":1}],"oa_status":"green","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1346926","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc1346926?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1346926","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JVI.80.3.1271-1279.2006","host_type":"publisher"},{"url":"https://doi.org/10.1128/jvi.80.3.1271-1279.2006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16415004","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/a1319410-79fc-40d5-afd2-cd58e45c838b","host_type":"repository"}],"fields_of_study":["Viral Infections and Immunology Research","Viral gastroenteritis research and epidemiology","Animal Virus Infections Studies","Medicine","Biology","Animals","Base Sequence","Enteroviruses, Porcine","Hepacivirus","Humans","Models, Molecular","Molecular Sequence Data","Mutagenesis, Site-Directed","Nucleic Acid Conformation","RNA, Messenger","RNA, Viral","Sequence Homology, Nucleic Acid","Species Specificity","Swine"],"mesh_terms":["Animals","Base Sequence","Enteroviruses, Porcine","Humans","Models, Molecular","Molecular Sequence Data","Nucleic Acid Conformation","RNA, Messenger","RNA, Viral","Sequence Homology, Nucleic Acid","Species Specificity","Swine","Hepacivirus","Mutagenesis, Site-Directed"],"keywords":["Picornavirus","Biology","Virology","Internal ribosome entry site","Picornaviridae","RNA","Ribosome","Virus","Translation (biology)","Genetics","Messenger RNA","Enterovirus","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T16:22:33.503113Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}