{"doi":"10.1128/jvi.72.2.1699-1703.1998","title":"Construction and Characterization of a Hybrid Mouse Mammary Tumor Virus/Murine Leukemia Virus-Based Retroviral Vector","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>Mouse mammary tumor virus (MMTV)-based vectors are characterized by low titers. In an effort to transfer MMTV-specific regulation of gene expression to a more efficient murine leukemia virus (MLV) vector, we have replaced the complete 3′ U3 region of MLV with the complete U3 region of MMTV. Virus titers were not significantly affected by this modification, there was no impairment of reverse transcription and integration, and after infection of cells, the MMTV promoter is duplicated and translocated to the 5′ long terminal repeat, resulting in glucocorticoid-regulatable RNA expression.</jats:p>","journal":"Journal of Virology","year":1998,"id":15236,"datarank":0.555225505094086,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.12166974140966119,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.12166974140966119,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":6,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":117030,"name":"Feride Öztürk","orcid":null,"position":1,"is_corresponding":false},{"id":117031,"name":"Brian Salmons","orcid":null,"position":2,"is_corresponding":false},{"id":117032,"name":"Walter H. Günzburg","orcid":null,"position":3,"is_corresponding":false},{"id":117029,"name":"Robert M. Saller","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9445081","pmcid":"PMC124659","openalex_id":"https://openalex.org/W2159674672","authors":[],"funders":[],"total_grants":0,"fwci":0.4493,"citation_percentile":0.62587861,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1},{"year":2016,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jvi.asm.org/content/jvi/72/2/1699.full.pdf","host_type":"journal"},{"url":"https://jvi.asm.org/content/jvi/72/2/1699.full.pdf","host_type":"BRONZE"},{"url":"https://jvi.asm.org/content/jvi/72/2/1699.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JVI.72.2.1699-1703.1998","host_type":"publisher"},{"url":"https://doi.org/10.1128/jvi.72.2.1699-1703.1998","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9445081","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC124659","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/124659","host_type":"repository"}],"fields_of_study":["interferon and immune responses","Virus-based gene therapy research","RNA Interference and Gene Delivery","Biology","Medicine","Animals","Gene Transfer Techniques","Genetic Vectors","Leukemia Virus, Murine","Mammary Tumor Virus, Mouse","Mice"],"mesh_terms":["Animals","Genetic Vectors","Mammary Tumor Virus, Mouse","Leukemia Virus, Murine","Gene Transfer Techniques","Mice"],"keywords":["Biology","Mouse mammary tumor virus","Long terminal repeat","Murine leukemia virus","Virology","Virus","Viral vector","Vector (molecular biology)","Gammaretrovirus","Retrovirus","Gene","Molecular biology","Gene expression","Genetics","Recombinant DNA"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T16:54:31.739742Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}