{"doi":"10.1128/jvi.68.5.3183-3192.1994","title":"Encephalomyocarditis virus internal ribosomal entry site RNA-protein interactions","abstract":"<jats:p>Translational initiation of encephalomyocarditis virus (EMCV) mRNA occurs by ribosomal entry into the 5' nontranslated region of the EMCV mRNA, rather than by ribosomal scanning. Internal ribosomal binding requires a cis-acting element termed the internal ribosomal entry site (IRES). IRES elements have been proposed to be involved in the translation of picornavirus mRNAs and some cellular mRNAs. Internal ribosome binding likely requires the interaction of trans-acting factors that recognize both the mRNA and the ribosomal complex. Five cellular proteins (p52, p57, p70, p72, and p100) cross-link the EMCV IRES or fragments of the IRES. For one of these proteins, p57, binding to the IRES correlates with translation. Recently, p57 was identified to be very similar, if not identical, to polypyrimidine tract-binding protein. On the basis of cross-linking results with 21 different EMCV IRES fragments and cytoplasmic HeLa extract or rabbit reticulocyte lysate as the source of polypeptides, consensus binding sites for p52, p57, p70, and p100 are proposed. It is suggested that each of these proteins recognizes primarily a structural feature of the RNA rather than a specific sequence.</jats:p>","journal":"Journal of Virology","year":1994,"id":21565,"datarank":2.8434475449402132,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":2.282797102197708,"self_endowment_contribution":0.5606504427425053,"citer_contribution":2.282797102197708,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":40,"citers_with_citation_signal":38,"citers_with_endowment":38,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":138368,"name":"E Wimmer","orcid":null,"position":1,"is_corresponding":false},{"id":138367,"name":"G W Witherell","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8151781","pmcid":"PMC236809","openalex_id":"https://openalex.org/W1576676044","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"AI-15122","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"AI-08482","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"AI-32100","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01AI032100-07","title":"NOVEL CELLULAR REGULATORY FACTORS IN VIRAL TRANSLATION"}],"total_grants":4,"fwci":4.9911,"citation_percentile":0.95511619,"influential_citations":1,"citation_trend":[{"year":2012,"count":1},{"year":2020,"count":1},{"year":2022,"count":3},{"year":2023,"count":1}],"oa_status":"bronze","license":"ASM Journals Non-Commercial TDM","oa_locations":[{"url":"https://jvi.asm.org/content/jvi/68/5/3183.full.pdf","host_type":"journal"},{"url":"https://jvi.asm.org/content/jvi/68/5/3183.full.pdf","host_type":"BRONZE"},{"url":"https://jvi.asm.org/content/jvi/68/5/3183.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/jvi.68.5.3183-3192.1994","host_type":"publisher"},{"url":"https://doi.org/10.1128/jvi.68.5.3183-3192.1994","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8151781","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/236809","host_type":"repository"},{"url":"https://dx.doi.org/10.1128/jvi.68.5.3183-3192.1994","host_type":""}],"fields_of_study":["Viral Infections and Immunology Research","RNA and protein synthesis mechanisms","RNA regulation and disease","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Base Sequence","Cell-Free System","Cross-Linking Reagents","Encephalomyocarditis virus","HeLa Cells","Humans","Molecular Sequence Data","Nucleic Acid Conformation","Peptide Chain Initiation, Translational","RNA, Messenger","RNA, Viral","Regulatory Sequences, Nucleic Acid","Reticulocytes","Ribosomes","Structure-Activity Relationship","Trans-Activators","Ultraviolet Rays"],"mesh_terms":["Base Sequence","Cell-Free System","Cross-Linking Reagents","Encephalomyocarditis virus","HeLa Cells","Humans","Molecular Sequence Data","Nucleic Acid Conformation","Peptide Chain Initiation, Translational","Regulatory Sequences, Nucleic Acid","Reticulocytes","Ribosomes","RNA, Messenger","RNA, Viral","Structure-Activity Relationship","Ultraviolet Rays","Trans-Activators","Hela Cells"],"keywords":["Internal ribosome entry site","Polypyrimidine tract-binding protein","Biology","Picornavirus","Ribosomal binding site","Ribosome","Translation (biology)","Eukaryotic initiation factor","Eukaryotic Ribosome","Messenger RNA","Eukaryotic translation","Molecular biology","Ribosomal RNA","RNA","RNA-binding protein","Cell biology","Genetics","Gene","Reticulocytes","Base Sequence","Cell-Free System","Ultraviolet Rays","Molecular Sequence Data","Regulatory Sequences, Nucleic Acid","Structure-Activity Relationship","Cross-Linking Reagents","Trans-Activators","Humans","Nucleic Acid Conformation","RNA, Viral","RNA, Messenger","Encephalomyocarditis virus","Peptide Chain Initiation, Translational","Ribosomes","HeLa Cells"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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