{"doi":"10.1128/jvi.67.1.112-118.1993","title":"Mouse mammary tumor virus with rearranged long terminal repeats causes murine lymphomas","abstract":"<jats:p>Mouse mammary tumor virus (MMTV) is a slowly transforming retrovirus associated primarily with the induction of mammary tumors. It is widely accepted that T-cell lymphomas of various mouse strains are associated with extra proviruses of MMTV. These extra proviruses showed site-specific rearrangements in the U3 region of long terminal repeats (LTRs), consisting of about 400 nucleotide deletions and occasional substitution resulting in unique tandem repeats. However, the question of whether these mutant MMTVs cause lymphomas has not been experimentally resolved. Here we present distinct evidence that they do. We constructed chimeric MMTVs by replacing the LTR of the recently constructed pathogenic MMTV provirus clone with rearranged LTRs of MMTV proviruses obtained from two DBA/2 mouse lymphoma cell lines, MLA and DL-8, and inoculated them into BALB/c mice. These mice developed lymphomas, but no mammary tumors, 4 to 11 months postinoculation, whereas the original pathogenic MMTV clone alone induced mammary tumors. These results showed that the tissue specificity of MMTV tumorigenesis is determined by the LTR structures.</jats:p>","journal":"Journal of Virology","year":1993,"id":16551,"datarank":2.4608806968814774,"base_score":3.970291913552122,"endowment":3.970291913552122,"self_citation_contribution":0.5955437870328184,"citation_network_contribution":1.865336909848659,"self_endowment_contribution":0.5955437870328184,"citer_contribution":1.865336909848659,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":47,"citers_with_citation_signal":45,"citers_with_endowment":45,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":121739,"name":"K Kakimi","orcid":null,"position":1,"is_corresponding":false},{"id":121238,"name":"H Tanaka","orcid":null,"position":2,"is_corresponding":false},{"id":121237,"name":"A Murakami","orcid":null,"position":3,"is_corresponding":false},{"id":121741,"name":"Y Nakagawa","orcid":null,"position":4,"is_corresponding":false},{"id":121743,"name":"Y Kubo","orcid":null,"position":5,"is_corresponding":false},{"id":121745,"name":"Y Yamada","orcid":null,"position":6,"is_corresponding":false},{"id":121747,"name":"H Hiai","orcid":null,"position":7,"is_corresponding":false},{"id":121749,"name":"K Kuribayashi","orcid":null,"position":8,"is_corresponding":false},{"id":121751,"name":"T Masuda","orcid":null,"position":9,"is_corresponding":false},{"id":121236,"name":"S Yanagawa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.970291913552122,"endowment":3.970291913552122,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7677952","pmcid":"PMC237343","openalex_id":"https://openalex.org/W1960355296","authors":[],"funders":[],"total_grants":0,"fwci":1.7133,"citation_percentile":0.84751324,"influential_citations":4,"citation_trend":[{"year":2012,"count":1},{"year":2016,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2022,"count":2},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jvi.asm.org/content/jvi/67/1/112.full.pdf","host_type":"journal"},{"url":"https://jvi.asm.org/content/jvi/67/1/112.full.pdf","host_type":"BRONZE"},{"url":"https://jvi.asm.org/content/jvi/67/1/112.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/jvi.67.1.112-118.1993","host_type":"publisher"},{"url":"https://doi.org/10.1128/jvi.67.1.112-118.1993","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7677952","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/237343","host_type":"repository"}],"fields_of_study":["Immunotherapy and Immune Responses","Animal Virus Infections Studies","interferon and immune responses","Medicine","Biology","Animals","Base Sequence","Gene Rearrangement","Lymphoma, T-Cell","Mammary Tumor Virus, Mouse","Mice","Mice, Inbred BALB C","Molecular Sequence Data","Proviruses","RNA","Repetitive Sequences, Nucleic Acid"],"mesh_terms":["Animals","Base Sequence","Mammary Tumor Virus, Mouse","Mice, Inbred BALB C","Molecular Sequence Data","Proviruses","Repetitive Sequences, Nucleic Acid","RNA","Gene Rearrangement","Lymphoma, T-Cell","Mice"],"keywords":["Provirus","Long terminal repeat","Biology","Mouse mammary tumor virus","Retrovirus","clone (Java method)","Virology","Mammary tumor","Lymphoma","Carcinogenesis","Virus","Molecular biology","Murine leukemia virus","Direct repeat","Cancer research","Gene","Genetics","Cancer","Genome","Immunology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-02T11:11:40.760381Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}