{"doi":"10.1128/jvi.06501-11","title":"Hsp70 Protein Positively Regulates Rabies Virus Infection","abstract":"<jats:title>ABSTRACT</jats:title><jats:p>The Hsp70 chaperone plays a central role in multiple processes within cells, including protein translation, folding, intracellular trafficking, and degradation. This protein is implicated in the replication of numerous viruses. We have shown that rabies virus infection induced the cellular expression of Hsp70, which accumulated in Negri body-like structures, where viral transcription and replication take place. In addition, Hsp70 is present in both nucleocapsids purified from infected cells and in purified virions. Hsp70 has been shown to interact with the nucleoprotein N. The downregulation of Hsp70, using specific chaperone inhibitors, such as quercetin or RNA interference, resulted in a significant decrease of the amount of viral mRNAs, viral proteins, and virus particles. These results indicate that Hsp70 has a proviral function during rabies virus infection and suggest that Hsp70 is involved in at least one stage(s) of the viral life cycle, such as viral transcription, translation, and/or production. The mechanism by which Hsp70 controls viral infection will be discussed.</jats:p>","journal":"Journal of Virology","year":2012,"id":17122,"datarank":5.424291467238141,"base_score":4.941642422609304,"endowment":4.941642422609304,"self_citation_contribution":0.7412463633913957,"citation_network_contribution":4.683045103846745,"self_endowment_contribution":0.7412463633913957,"citer_contribution":4.683045103846745,"corpus_percentile":null,"corpus_rank":null,"citation_count":139,"citer_count":136,"citers_with_citation_signal":118,"citers_with_endowment":118,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":123596,"name":"Aurore Vidy","orcid":null,"position":1,"is_corresponding":false},{"id":123597,"name":"Baptiste Fouquet","orcid":null,"position":2,"is_corresponding":false},{"id":123598,"name":"Danielle Blondel","orcid":null,"position":3,"is_corresponding":false},{"id":123595,"name":"Xavier Lahaye","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.941642422609304,"endowment":4.941642422609304,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22345440","pmcid":"PMC3347396","openalex_id":"https://openalex.org/W2102133406","authors":[],"funders":[],"total_grants":0,"fwci":3.6273,"citation_percentile":0.93834684,"influential_citations":6,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":10},{"year":2014,"count":8},{"year":2015,"count":8},{"year":2016,"count":14},{"year":2017,"count":8},{"year":2018,"count":5},{"year":2019,"count":14},{"year":2020,"count":12},{"year":2021,"count":18},{"year":2022,"count":10},{"year":2023,"count":13},{"year":2024,"count":9},{"year":2025,"count":8},{"year":2026,"count":1}],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jvi.asm.org/content/jvi/86/9/4743.full.pdf","host_type":"journal"},{"url":"https://jvi.asm.org/content/jvi/86/9/4743.full.pdf","host_type":"BRONZE"},{"url":"https://jvi.asm.org/content/jvi/86/9/4743.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JVI.06501-11","host_type":"publisher"},{"url":"https://doi.org/10.1128/jvi.06501-11","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22345440","host_type":"repository"},{"url":"https://hal.science/hal-02988499","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3347396","host_type":"repository"}],"fields_of_study":["Heat shock proteins research","Bacillus and Francisella bacterial research","Yersinia bacterium, plague, ectoparasites research","Medicine","Biology","Animals","Cell Line","Cricetinae","Gene Expression","Gene Expression Regulation","HSP70 Heat-Shock Proteins","Humans","Nucleocapsid Proteins","Protein Binding","RNA Interference","RNA, Viral","Rabies virus","Virus Replication"],"mesh_terms":["Animals","Cell Line","Gene Expression Regulation","Cricetinae","Humans","Protein Binding","Rabies virus","RNA, Viral","Virus Replication","Gene Expression","HSP70 Heat-Shock Proteins","Nucleocapsid Proteins","RNA Interference"],"keywords":["Biology","Viral replication","Viral structural protein","Hsp70","Nucleoprotein","Rabies virus","Virology","Transcription (linguistics)","Viral protein","Virus","Viral entry","Viral life cycle","Chaperone (clinical)","Mononegavirales","Cell biology","Heat shock protein","Viral disease","Paramyxoviridae","Gene","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Responsible consumption and production"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"refseq"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-02T17:05:18.355242Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}