{"doi":"10.1128/jvi.03198-15","title":"Analysis of Assembly and Budding of Lujo Virus","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>The recently identified arenavirus Lujo virus (LUJV) causes fatal hemorrhagic fever in humans. We analyzed its mechanism of viral release driven by matrix protein Z and the cell surface glycoprotein precursor GPC. The L domains in Z are required for efficient virus-like particle release, but Tsg101, ALIX/AIP1, and Vps4A/B are unnecessary for budding. LUJV GPC is cleaved by site 1 protease (S1P) at the RKLM motif, and treatment with the S1P inhibitor PF-429242 reduced LUJV production.</jats:p>","journal":"Journal of Virology","year":2016,"id":684469,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1760232,"name":"Jacqueline Weyer","orcid":"0000-0001-9471-2890","position":1,"is_corresponding":false},{"id":557139,"name":"Nadia Storm","orcid":"0000-0002-2596-0468","position":2,"is_corresponding":false},{"id":1699121,"name":"Yukiko Miyazaki","orcid":null,"position":3,"is_corresponding":false},{"id":819225,"name":"Petrus Jansen van Vuren","orcid":"0000-0003-2862-7983","position":4,"is_corresponding":false},{"id":1788184,"name":"Janusz Tadeusz Paweska","orcid":null,"position":5,"is_corresponding":false},{"id":1545582,"name":"Jiro Yasuda","orcid":null,"position":6,"is_corresponding":false},{"id":1553281,"name":"Shuzo Urata","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Analysis of Assembly and Budding of Lujo Virus","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>The recently identified arenavirus Lujo virus (LUJV) causes fatal hemorrhagic fever in humans. We analyzed its mechanism of viral release driven by matrix protein Z and the cell surface glycoprotein precursor GPC. The L domains in Z are required for efficient virus-like particle release, but Tsg101, ALIX/AIP1, and Vps4A/B are unnecessary for budding. LUJV GPC is cleaved by site 1 protease (S1P) at the RKLM motif, and treatment with the S1P inhibitor PF-429242 reduced LUJV production.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26719243","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4810620","host_type":"repository"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JVI.03198-15","host_type":"publisher"}],"fields_of_study":["Animals","Cell Line","Humans","Lujo virus","Viral Proteins","Virus Assembly","Virus Release"],"mesh_terms":["Animals","Cell Line","Humans","Lujo virus","Viral Proteins","Virus Assembly","Virus Release"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T14:11:57.721509Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}