{"doi":"10.1128/jvi.02731-15","title":"Determination of Sequences Required for Human Endogenous Retrovirus K Transduction and Its Recognition by Foreign Retroviral Virions","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Sequences necessary for transduction of human endogenous retrovirus (HERV)-K\n            <jats:sub>con</jats:sub>\n            , a consensus of the HERV-K(HML-2) family, were analyzed and found to reside in the leader/\n            <jats:italic>gag</jats:italic>\n            region. They act in an orientation-dependent way and consist of at least two sites working together. Having defined these sequences, we exploited this information to produce a simple system to investigate to what extent virions of HERV-K\n            <jats:sub>con</jats:sub>\n            , murine leukemia virus, and HIV-1 have the ability to transduce each other's genomes, leading to potential contamination of gene therapy vectors.\n          </jats:p>","journal":"Journal of Virology","year":2016,"id":589769,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":754883,"name":"Nathan P. Sweeney","orcid":"0000-0003-0060-0463","position":1,"is_corresponding":false},{"id":1508941,"name":"Raffaele de Leon","orcid":null,"position":2,"is_corresponding":false},{"id":767432,"name":"Gillian Wills","orcid":null,"position":3,"is_corresponding":false},{"id":1508942,"name":"Mark J. Robinson","orcid":null,"position":4,"is_corresponding":false},{"id":626580,"name":"Myra O. McClure","orcid":"0000-0002-5494-407X","position":5,"is_corresponding":false},{"id":1250523,"name":"Otto Erlwein","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Determination of Sequences Required for Human Endogenous Retrovirus K Transduction and Its Recognition by Foreign Retroviral Virions","abstract":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            Sequences necessary for transduction of human endogenous retrovirus (HERV)-K\n            <jats:sub>con</jats:sub>\n            , a consensus of the HERV-K(HML-2) family, were analyzed and found to reside in the leader/\n            <jats:italic>gag</jats:italic>\n            region. They act in an orientation-dependent way and consist of at least two sites working together. Having defined these sequences, we exploited this information to produce a simple system to investigate to what extent virions of HERV-K\n            <jats:sub>con</jats:sub>\n            , murine leukemia virus, and HIV-1 have the ability to transduce each other's genomes, leading to potential contamination of gene therapy vectors.\n          </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26719267","pmcid":"PMC4810645","openalex_id":"https://openalex.org/W2275798086","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.08363485,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jvi.asm.org/content/jvi/90/6/3243.full.pdf","host_type":"journal"},{"url":"https://jvi.asm.org/content/jvi/90/6/3243.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JVI.02731-15","host_type":"publisher"},{"url":"https://doi.org/10.1128/jvi.02731-15","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26719267","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4810645","host_type":"repository"}],"fields_of_study":["Chromosomal and Genetic Variations","CRISPR and Genetic Engineering","RNA and protein synthesis mechanisms","Cell Line","DNA, Viral","Endogenous Retroviruses","Gene Products, gag","Genetic Therapy","Genetic Vectors","HIV-1","Humans","Leukemia Virus, Murine","Transduction, Genetic"],"mesh_terms":["Cell Line","DNA, Viral","Genetic Vectors","Humans","Leukemia Virus, Murine","Transduction, Genetic","Genetic Therapy","HIV-1","Gene Products, gag","Endogenous Retroviruses"],"keywords":["Biology","Transduction (biophysics)","Retrovirus","Endogenous retrovirus","Murine leukemia virus","Virology","Genome","Gene","Genetics","Endogeny","Feline leukemia virus","Virus","Group-specific antigen","Computational biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T06:17:09.525352Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}