{"doi":"10.1128/jvi.02329-20","title":"pH-Induced Conformational Changes of Human Bocavirus Capsids","abstract":"Human bocaviruses (HBoVs) are associated with disease in humans. However, the lack of an animal model and a versatile cell culture system to study their life cycle limits the ability to develop specific treatments or vaccines. This study presents the structure of HBoV2, at 2.7 Å resolution, determined for comparison to the existing HBoV1, HBoV3, and HBoV4 structures, to enable the molecular characterization of strain and genus-specific capsid features contributing to tissue tropism and antigenicity. Furthermore, HBoV1 and HBoV2 structures determined under acidic conditions provide insight into capsid changes associated with endosomal and gastrointestinal acidification. Structural rearrangements of the capsid VP N-terminus, at the base of the 5-fold channel, demonstrate a disordering of a \"basket\" motif as pH decreases. These observations begin to unravel the molecular mechanism of HBoV infection and provide information for control strategies.","journal":"Journal of Virology","year":2021,"id":192646,"datarank":0.5411508466902477,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.1684148492220476,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.1684148492220476,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":7,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311790,"name":"Mario Mietzsch","orcid":"0000-0001-8957-3363","position":1,"is_corresponding":false},{"id":311794,"name":"Paul R. Chipman","orcid":"0000-0003-3652-4087","position":2,"is_corresponding":false},{"id":543960,"name":"Kangkang Song","orcid":"0000-0002-5499-5221","position":3,"is_corresponding":false},{"id":458526,"name":"Xu Chen","orcid":"0000-0002-9870-7287","position":4,"is_corresponding":false},{"id":759825,"name":"John Spear","orcid":"0000-0002-4210-791X","position":5,"is_corresponding":false},{"id":740486,"name":"Duncan Sousa","orcid":null,"position":6,"is_corresponding":false},{"id":311795,"name":"Robert McKenna","orcid":"0000-0002-2792-935X","position":7,"is_corresponding":false},{"id":369529,"name":"Maria Söderlund‐Venermo","orcid":"0000-0002-4582-8317","position":8,"is_corresponding":false},{"id":311796,"name":"Mavis Agbandje‐McKenna","orcid":"0000-0003-0565-5578","position":9,"is_corresponding":false},{"id":760387,"name":"Mengxiao Luo","orcid":null,"position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:49:43.496702Z","pmid":"33472934","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}