{"doi":"10.1128/jvi.02198-20","title":"Immune Responses and Viral Persistence in Simian/Human Immunodeficiency Virus SHIV.C.CH848-Infected Rhesus Macaques","abstract":"SHIVs have been extensively used in a nonhuman primate (NHP) model for HIV research. In this study, we investigated viral reservoirs in tissues and immune responses in an NHP model inoculated with newly generated transmitted/founder HIV-1 clade C-based SHIV.C.CH848. The data show that transmitted founder (T/F) SHIVC infection of macaques more closely recapitulates the virological and clinical features of HIV infection, including persistent viremia and viral rebound once antiretroviral therapy is discontinued. These results suggest this CCR5-tropic, SHIVC strain is valuable for testing responses to HIV vaccines and therapeutics.","journal":"Journal of Virology","year":2021,"id":192677,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9556,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":280560,"name":"Anya M. Bauer","orcid":"0000-0002-5793-0079","position":1,"is_corresponding":false},{"id":490873,"name":"Hong Lü","orcid":"0000-0001-5593-6533","position":2,"is_corresponding":false},{"id":741089,"name":"Xiaolei Wang","orcid":"0000-0003-3403-1174","position":3,"is_corresponding":false},{"id":490874,"name":"Xueling Wu","orcid":"0000-0002-9752-3734","position":4,"is_corresponding":false},{"id":263024,"name":"Katharine J. Bar","orcid":"0000-0002-9773-0071","position":5,"is_corresponding":false},{"id":280543,"name":"Hui Li","orcid":"0000-0001-7231-8219","position":6,"is_corresponding":false},{"id":244938,"name":"Dongfang Liu","orcid":"0000-0002-7295-8088","position":7,"is_corresponding":false},{"id":253820,"name":"George M. Shaw","orcid":"0000-0002-2338-4532","position":8,"is_corresponding":false},{"id":336400,"name":"Ronald S. Veazey","orcid":"0000-0002-6298-2391","position":9,"is_corresponding":false},{"id":408492,"name":"Huanbin Xu","orcid":"0000-0003-1742-0979","position":10,"is_corresponding":false},{"id":408490,"name":"Widade Ziani","orcid":"0000-0002-7632-9772","position":0,"is_corresponding":true}],"reference_count":106,"raw_metadata":null,"created_at":"2026-07-18T23:49:43.496702Z","pmid":"33568508","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}