{"doi":"10.1128/jvi.02184-21","title":"Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice","abstract":"Emerging SARS-CoV-2 VoC are posing new problems regarding vaccine and monoclonal antibody efficacy. To better understand immune evasion tactics of the VoC, we utilized passive immunization to study the effect of early-pandemic SARS-CoV-2 HCP against, Alpha, Beta, and Delta VoC. We observed that HCP from a human infected with the original SARS-CoV-2 was unable to control lethality of Alpha, Beta, or Delta VoC in the K18-hACE2 transgenic mouse model of SARS-CoV-2 infection. Our findings demonstrate that passive immunization can be used as a model to evaluate immune evasion of emerging VoC strains.","journal":"Journal of Virology","year":2022,"id":255058,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9647,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":501279,"name":"Alexander M. Horspool","orcid":"0000-0003-4115-0331","position":1,"is_corresponding":false},{"id":805902,"name":"Brynnan P. Russ","orcid":null,"position":2,"is_corresponding":false},{"id":2361,"name":"Chengjin Ye","orcid":"0000-0002-1934-9494","position":3,"is_corresponding":false},{"id":805124,"name":"Katherine S. Lee","orcid":"0000-0002-2067-1405","position":4,"is_corresponding":false},{"id":331846,"name":"Michael T. Winters","orcid":"0000-0003-3532-928X","position":5,"is_corresponding":false},{"id":399400,"name":"Justin R. Bevere","orcid":"0000-0003-0096-7935","position":6,"is_corresponding":false},{"id":863354,"name":"Olivia A. Miller","orcid":"0009-0004-5327-9778","position":7,"is_corresponding":false},{"id":863353,"name":"Nathaniel A. Rader","orcid":"0000-0002-6134-3133","position":8,"is_corresponding":false},{"id":592364,"name":"Melissa Cooper","orcid":"0000-0003-4337-8356","position":9,"is_corresponding":false},{"id":805903,"name":"Theodore Kieffer","orcid":null,"position":10,"is_corresponding":false},{"id":576114,"name":"Julien Sourimant","orcid":"0000-0002-1660-1666","position":11,"is_corresponding":false},{"id":108342,"name":"Alexander L. Greninger","orcid":"0000-0002-7443-0527","position":12,"is_corresponding":false},{"id":228962,"name":"Richard K. Plemper","orcid":"0000-0003-2034-2107","position":13,"is_corresponding":false},{"id":406424,"name":"James Denvir","orcid":"0000-0001-8836-6653","position":14,"is_corresponding":false},{"id":805904,"name":"Holly A. Cyphert","orcid":null,"position":15,"is_corresponding":false},{"id":399402,"name":"Mariette Barbier","orcid":"0000-0002-3250-3636","position":16,"is_corresponding":false},{"id":245288,"name":"Jordi B. Torrelles","orcid":"0000-0001-7702-5941","position":17,"is_corresponding":false},{"id":331854,"name":"Iván Martínez","orcid":"0000-0001-7544-3314","position":18,"is_corresponding":false},{"id":2423,"name":"Luis Martínez‐Sobrido","orcid":"0000-0001-7084-0804","position":19,"is_corresponding":false},{"id":399401,"name":"F. Heath Damron","orcid":"0000-0002-3140-402X","position":20,"is_corresponding":false},{"id":399398,"name":"Ting Y. Wong","orcid":"0000-0003-4569-8580","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:25:12.987829Z","pmid":"35080423","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}