{"doi":"10.1128/jvi.02048-18","title":"The Extended C-Terminal Region of Influenza C Virus Nucleoprotein Is Important for Nuclear Import and Ribonucleoprotein Activity","abstract":"<jats:p>\n            As a member of the\n            <jats:italic>Orthomyxoviridae</jats:italic>\n            family, the polymerase complex of the influenza C virus structurally resembles its influenza A and influenza B virus counterparts, but the nucleoprotein differs by possessing an extra C-terminal region. We have characterized this region in view of nuclear import and interaction with the importin α protein family. Our results demonstrate the functional significance of a previously uncharacterized region on\n            <jats:italic>Orthomyxoviridae</jats:italic>\n            nucleoprotein (NP). Based on this work, we propose that importin α binding to influenza C virus NP is regulated by a long bipartite nuclear localization signal. Since the sequence of influenza D virus NP shares high homology to that of the influenza C virus, this work will also shed light on how influenza D virus NP functions.\n          </jats:p>","journal":"Journal of Virology","year":2019,"id":590978,"datarank":0.6067725932654013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.23403659579720118,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.23403659579720118,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":10,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1125830,"name":"Chun-Yeung Lo","orcid":null,"position":1,"is_corresponding":false},{"id":1512007,"name":"Chris Ka-Pun Mok","orcid":null,"position":2,"is_corresponding":false},{"id":1512008,"name":"Paul Kay-Sheung Chan","orcid":null,"position":3,"is_corresponding":false},{"id":1512009,"name":"Pang-Chui Shaw","orcid":null,"position":4,"is_corresponding":false},{"id":681146,"name":"Yun-Sang Tang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Extended C-Terminal Region of Influenza C Virus Nucleoprotein Is Important for Nuclear Import and Ribonucleoprotein Activity","abstract":"<jats:p>\n            As a member of the\n            <jats:italic>Orthomyxoviridae</jats:italic>\n            family, the polymerase complex of the influenza C virus structurally resembles its influenza A and influenza B virus counterparts, but the nucleoprotein differs by possessing an extra C-terminal region. We have characterized this region in view of nuclear import and interaction with the importin α protein family. Our results demonstrate the functional significance of a previously uncharacterized region on\n            <jats:italic>Orthomyxoviridae</jats:italic>\n            nucleoprotein (NP). Based on this work, we propose that importin α binding to influenza C virus NP is regulated by a long bipartite nuclear localization signal. Since the sequence of influenza D virus NP shares high homology to that of the influenza C virus, this work will also shed light on how influenza D virus NP functions.\n          </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30814281","pmcid":"PMC6475786","openalex_id":null,"authors":[],"funders":[{"funder_name":"Hong Kong Research Grant Council","grant_id":"T11-705/14N","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"https://journals.asm.org/non-commercial-tdm-license","oa_locations":[{"url":"https://jvi.asm.org/content/jvi/93/9/e02048-18.full.pdf","host_type":"publisher"},{"url":"https://journals.asm.org/doi/pdf/10.1128/JVI.02048-18","host_type":"publisher"}],"fields_of_study":["Active Transport, Cell Nucleus","Amino Acid Motifs","Cell Nucleus","HEK293 Cells","Humans","Gammainfluenzavirus","Protein Domains","Ribonucleoproteins","Viral Core Proteins","alpha Karyopherins"],"mesh_terms":["Cell Nucleus","Humans","alpha Karyopherins","Ribonucleoproteins","Viral Core Proteins","Amino Acid Motifs","Active Transport, Cell Nucleus","HEK293 Cells","Protein Domains","Gammainfluenzavirus"],"keywords":["Influenza","Nuclear localization signal","NLS","NP","nucleoprotein","Importin Alpha"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T13:29:36.892745Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}