{"doi":"10.1128/jvi.01987-22","title":"Drug Screening for Hepatitis A Virus (HAV): Nicotinamide Inhibits c-Jun Expression and HAV Replication","abstract":"Drug screening methods targeting HAV IRES-mediated translation with reporter assays are attractive and useful for drug repurposing. Nicotinamide (vitamin B3, niacin) has been shown to effectively inhibit HAV replication. Transcription complex activator protein 1 (AP-1) plays an important role in the transcriptional regulation of cellular immunity or viral replication. The results of this study provide evidence that AP-1 is involved in HAV replication and plays a role in the HAV life cycle. In addition, nicotinamide was shown to suppress HAV replication partly by inhibiting AP-1 activity and HAV IRES-mediated translation. Nicotinamide may be useful for the control of acute HAV infection by inhibiting cellular AP-1 activity during HAV infection processes.","journal":"Journal of Virology","year":2023,"id":357594,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":363994,"name":"Ryota Masuzaki","orcid":"0000-0001-5118-4397","position":1,"is_corresponding":false},{"id":230990,"name":"Hiroaki Okamoto","orcid":"0000-0003-0827-0964","position":2,"is_corresponding":false},{"id":1107381,"name":"Toshikatsu Shibata","orcid":"0000-0003-3235-4893","position":3,"is_corresponding":false},{"id":615986,"name":"Mitsuhiko Moriyama","orcid":"0000-0002-4617-508X","position":4,"is_corresponding":false},{"id":1107382,"name":"Hirofumi Kogure","orcid":"0000-0002-2355-7309","position":5,"is_corresponding":false},{"id":748367,"name":"Tatsuo Kanda","orcid":"0000-0002-1654-5385","position":6,"is_corresponding":false},{"id":895972,"name":"Reina Sasaki","orcid":"0000-0003-2681-0776","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T01:13:39.186262Z","pmid":"36728416","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}