{"doi":"10.1128/jvi.01777-20","title":"People with HIV-1 Demonstrate Type 1 Interferon Refractoriness Associated with Upregulated USP18","abstract":", we demonstrated that refractory type 1 IFN responses were transferrable to HIV-1 uninfected target CD4+ T cells, and this phenomenon was mediated by type 1 IFN from HIV-1 infected cells. Type 1 IFN responses were partially restored by USP18 knockdown. Our findings illuminate a new mechanism by which HIV-1 contributes to innate immune dysfunction in PLWH, through the continuous production of type 1 IFN that induces a refractory state of responsiveness.","journal":"Journal of Virology","year":2021,"id":191702,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9618,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":665281,"name":"Ramy El–Diwany","orcid":"0000-0002-3224-6414","position":1,"is_corresponding":false},{"id":758067,"name":"Laura K. Cohen","orcid":null,"position":2,"is_corresponding":false},{"id":278650,"name":"Kimberly E. Rousseau","orcid":"0000-0003-3097-0289","position":3,"is_corresponding":false},{"id":3412,"name":"Christopher Y. K. Williams","orcid":"0000-0001-8867-1623","position":4,"is_corresponding":false},{"id":677952,"name":"Rebecca T. Veenhuis","orcid":"0000-0002-9899-6277","position":5,"is_corresponding":false},{"id":228276,"name":"Shruti H. Mehta","orcid":"0000-0002-2523-0959","position":6,"is_corresponding":false},{"id":292101,"name":"Joel N. Blankson","orcid":"0000-0002-9683-8021","position":7,"is_corresponding":false},{"id":237962,"name":"David L. Thomas","orcid":"0000-0002-0749-925X","position":8,"is_corresponding":false},{"id":355240,"name":"Andrea L. Cox","orcid":"0000-0002-9331-2462","position":9,"is_corresponding":false},{"id":434568,"name":"Ashwin Balagopal","orcid":"0000-0002-6143-3104","position":10,"is_corresponding":false},{"id":494501,"name":"Sho K. Sugawara","orcid":"0000-0002-5187-423X","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-18T23:49:35.285023Z","pmid":"33658340","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}