{"doi":"10.1128/jvi.01763-22","title":"KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle","abstract":"Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi sarcoma (KS), the plasmablastic form of multicentric Castleman's disease, and primary effusion lymphoma. In sub-Saharan Africa, KS is the most common HIV-related malignancy. KSHV encodes a viral protein kinase (vPK) that aids viral replication. To elucidate the interactions of vPK with cellular proteins in KSHV-infected cells, we used an affinity purification approach and identified host protein ubiquitin-specific peptidase 9X-linked (USP9X) as a potential interactor of vPK. Depletion of USP9X inhibits both viral reactivation and the production of infectious virions. Overall, our data suggest a proviral role for USP9X.","journal":"Journal of Virology","year":2023,"id":363623,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9719,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":429011,"name":"Praneet Sandhu","orcid":"0000-0001-6946-9497","position":1,"is_corresponding":false},{"id":334456,"name":"Jason P. Wong","orcid":"0000-0002-0710-3112","position":2,"is_corresponding":false},{"id":245439,"name":"Aadra P. Bhatt","orcid":"0000-0002-0134-6543","position":3,"is_corresponding":false},{"id":268852,"name":"Xiaoxi Liu","orcid":"0000-0002-1933-8613","position":4,"is_corresponding":false},{"id":258075,"name":"Sara J. Buhrlage","orcid":"0000-0003-4562-1823","position":5,"is_corresponding":false},{"id":411077,"name":"Brenda Temple","orcid":"0000-0002-9233-0191","position":6,"is_corresponding":false},{"id":18212,"name":"Michael B. Major","orcid":"0000-0002-6753-8513","position":7,"is_corresponding":false},{"id":263811,"name":"Blossom Damania","orcid":"0000-0002-9205-1774","position":8,"is_corresponding":false},{"id":334462,"name":"Danielle L. Chappell","orcid":"0000-0002-8217-3911","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T01:14:32.510714Z","pmid":"36995092","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}