{"doi":"10.1128/jvi.01752-22","title":"Interleukin-27 Promotes Divergent Effects on HIV-1 Infection in Peripheral Blood Mononuclear Cells through BST-2/Tetherin","abstract":"T lymphocytes. IL-27 has long been considered a potent inhibitor of HIV-1 replication, a notion based on several reports showing that this cytokine controls HIV-1 infection in peripheral blood mononuclear cells (PBMCs), monocyte-derived macrophages, and dendritic cells. However, our present results are contrary to the current knowledge that IL-27 acts only as a powerful downregulator of HIV-1 replication. We observed that IL-27 can either prevent or enhance viral growth in PBMCs, an outcome dependent on when this cytokine is added to the infected cells. We detected that the increase of HIV-1 dissemination is due to enhanced cell-to-cell transmission with the involvement of the interferon-induced HIV-1 restriction factor BST-2/Tetherin and CD11a (LFA-1), an integrin that participates in formation of virological synapse.","journal":"Journal of Virology","year":2023,"id":366659,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1123837,"name":"Pedro L. C. Ferreira","orcid":null,"position":1,"is_corresponding":false},{"id":1123330,"name":"Leandra Linhares‐Lacerda","orcid":"0000-0001-8246-3866","position":2,"is_corresponding":false},{"id":1123331,"name":"Rhaíssa C. Vieira","orcid":"0000-0002-3695-5154","position":3,"is_corresponding":false},{"id":415098,"name":"Bruno Cister-Alves","orcid":null,"position":4,"is_corresponding":false},{"id":1123838,"name":"Livia Gobbo","orcid":null,"position":5,"is_corresponding":false},{"id":1123332,"name":"Marcelo Ribeiro‐Alves","orcid":"0000-0002-8663-3364","position":6,"is_corresponding":false},{"id":1055972,"name":"Rubem F. S. Menna‐Barreto","orcid":"0000-0002-1352-0641","position":7,"is_corresponding":false},{"id":414344,"name":"Dumith Chequer Bou‐Habib","orcid":"0000-0003-0552-9045","position":8,"is_corresponding":false},{"id":414338,"name":"Jairo R. Temerozo","orcid":"0000-0002-8092-2149","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T01:14:59.372548Z","pmid":"36602368","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}