{"doi":"10.1128/jvi.01737-20","title":"Deep Gene Sequence Cluster Analyses of Multi-Virus-Infected Mucosal Tissue Reveal Enhanced Transmission of Acute HIV-1","abstract":"During heterosexual HIV-1 transmission, a genetic bottleneck occurs in the newly infected individual as the virus passes from the mucosa, leading to systemic infection with a single transmitted HIV-1 clone in the recipient. This bottleneck in the recipient has just been described (K. Klein et al., PLoS Pathog 14:e1006754, https://doi.org/10.1371/journal.ppat.1006754), and the mechanisms involved in this selection process have not been elucidated. However, understanding mucosal restriction is of the utmost importance for understanding dynamics of infections and for designing focused vaccines. Using our human penile and cervical mucosal tissue models for mixed HIV infections, we provide evidence that HIV-1 from acute/early infection, compared to that from chronic infection, can more efficiently traverse the mucosal epithelium and be transmitted to T cells, suggesting higher transmission fitness. This study focused on the role of the HIV-1 envelope in transmission and provides strong evidence that HIV transmission may involve breaking the mucosal lectin trap.","journal":"Journal of Virology","year":2020,"id":85297,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9472,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":403130,"name":"Immaculate Nankya","orcid":null,"position":1,"is_corresponding":false},{"id":437074,"name":"Gabrielle Nickel","orcid":null,"position":2,"is_corresponding":false},{"id":131901,"name":"Annette N. Ratcliff","orcid":null,"position":3,"is_corresponding":false},{"id":403127,"name":"Adam Meadows","orcid":null,"position":4,"is_corresponding":false},{"id":270619,"name":"Nicholas J. Hathaway","orcid":"0000-0001-9639-2894","position":5,"is_corresponding":false},{"id":242456,"name":"Jeffrey A. Bailey","orcid":"0000-0002-6899-8204","position":6,"is_corresponding":false},{"id":288610,"name":"Daniel J Stieh","orcid":"0009-0003-8523-1528","position":7,"is_corresponding":false},{"id":436298,"name":"Hannah M. Cheeseman","orcid":"0000-0001-9044-1341","position":8,"is_corresponding":false},{"id":436299,"name":"Ann M. Carias","orcid":"0000-0003-1305-254X","position":9,"is_corresponding":false},{"id":436300,"name":"Michael A. Lobritz","orcid":"0000-0003-3885-4936","position":10,"is_corresponding":false},{"id":436301,"name":"Jamie F. S. Mann","orcid":"0000-0001-7037-1286","position":11,"is_corresponding":false},{"id":436302,"name":"Yong Gao","orcid":"0000-0001-6352-8652","position":12,"is_corresponding":false},{"id":263030,"name":"Thomas J. Hope","orcid":"0000-0001-7183-8319","position":13,"is_corresponding":false},{"id":436303,"name":"Robin J. Shattock","orcid":"0000-0002-4936-1718","position":14,"is_corresponding":false},{"id":401456,"name":"Eric J. Arts","orcid":"0000-0002-4880-7968","position":15,"is_corresponding":false},{"id":436297,"name":"Katja Klein","orcid":"0000-0002-6479-4597","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:56:02.794896Z","pmid":"33177204","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}